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Leg Swelling

Leg swelling is a transient state of edema caused by prolonged sitting, and may occur even during walking in persons with poor circulation or during the later months of pregnancy. Some supplements that improve blood circulation may help with leg swelling.

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect leg swelling.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable Very High See all 3 studies
Symptoms of leg swelling and varicose veins appear to be fairly reliably reduced with the recommended oral doses of horse chestnut supplementation.
grade-b Minor Very High See all 5 studies
The leg swelling associated with chronic venous insufficiency appears to be significantly reduced secondary to treating the state of chronic venous insufficiency.
grade-c Notable Very High See 2 studies
Appears to reduce leg swelling secondary to the enhancement of blood flow. While the evidence is not overly robust, it is comparable if not better than the reference supplement of Horse Chestnut

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