Ketone Bodies Research Analysis

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect ketone bodies

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
Fish Oil	Minor	- See study	An increase in ketone bodies has been noted when fish oil is paired with a weight loss diet (relative to placebo)
Branched Chain Amino Acids	-	- See study	No significant alterations in formation of ketone bodies, which may be due to the ketogenic BCAA (leucine) being offset by the other two glucogenic ones
Colostrum	Minor	- See study	A decrease in ketone bodies in type II diabetics was noted with supplementation of colostrum daily for four weeks; the decrease was mild, and there was no protein containing placebo for comparison.
Medium-chain triglycerides	Minor	- See study	Has been implicated in increasing serum ketones more than other fatty acids.
Sodium Bicarbonate
Vitamin B3 (Niacin)

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.