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Ketone Bodies

Ketone bodies are small molecules that are produced in higher amounts during states of carbohydrate depletion, and are known to contribute to energy metabolism and may influence other aspects of the body.

Research analysis led by and reviewed by the Examine team.
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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Ketone Bodies.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Strong Very High See all 8 studies
When a ketogenic diet is followed, ketone bodies will increase considerably. Ketosis is compatible with a wide range of protein intakes as long as carbohydrate intake is low, but the most ketogenic diets will be the ones low in both carbohydrates and protein.
grade-c Minor - See study
An increase in ketone bodies has been noted when fish oil is paired with a weight loss diet (relative to placebo)
grade-c - - See study
No significant alterations in formation of ketone bodies, which may be due to the ketogenic BCAA (leucine) being offset by the other two glucogenic ones

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