Ketone Bodies
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect ketone bodies
| Grade | Level of Evidence [show legend] |
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
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Level of Evidence
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The amount of high quality evidence. The more
evidence, the more we can trust the results.
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Outcome |
Magnitude of effect
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The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
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Consistency of research results
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Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
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Notes |
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Strong
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Very High See all 8 studies |
When a ketogenic diet is followed, ketone bodies will increase considerably. Ketosis is compatible with a wide range of protein intakes as long as carbohydrate intake is low, but the most ketogenic diets will be the ones low in both carbohydrates and protein.
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Minor
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- See study |
An increase in ketone bodies has been noted when fish oil is paired with a weight loss diet (relative to placebo)
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- | - See study |
No significant alterations in formation of ketone bodies, which may be due to the ketogenic BCAA (leucine) being offset by the other two glucogenic ones
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