Intraocular Pressure Research Analysis

Things To Know & Note

IOP

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect intraocular pressure

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
Ginkgo biloba	-	Very High See all 3 studies	Despite the increase in ocular blood flow associated with repeated dosing of ginkgo biloba, there does not appear to be a significant modification of intraocular blood pressure in persons with normal IOP.
Coleus forskohlii	Minor	Very High See 2 studies	Eyedrops containing forskolin seem effective in reducing intraocular pressure (IOP), and while it seems effective orally those studies are currently confounded with the inclusion of other nutrients (and thus omitted from the HEM).
Melatonin	Minor	- See study	Oral supplementation of melatonin (500mcg) is able to reduce intraocular pressure in otherwise healthy persons
Astaxanthin	-	- See study
Cocoa Extract
Marijuana
CDP-choline

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.