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Intestinal Candidiasis (Candida Overgrowth)

Intestinal Candidiasis (IC) refers to an overgrowth of the Candida yeast genus in the small and large intestines. Yeast is a normal inhabitant of the human body and harmless in healthy people but can cause illness in certain populations, such as premature infants and immunocompromised individuals. Although exploratory studies suggest that the fungal “mycobiome” could play a role in a subgroup of IBS-D, there isn’t yet a conclusive link. Probiotics and antifungal drugs may prevent IC, but diets that restrict refined carbohydrates are ineffective.

Our evidence-based analysis on intestinal candidiasis (candida overgrowth) features 34 unique references to scientific papers.

Research analysis led by and reviewed by the Examine team.
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  12. ^ Brunella Posteraro, et al. Early diagnosis of candidemia in intensive care unit patients with sepsis: a prospective comparison of (1→3)-β-D-glucan assay, Candida score, and colonization index. Crit Care. (2011)
  13. ^ Mehmet Yekta Oncel, et al. Comparison of Lactobacillus reuteri and nystatin prophylaxis on Candida colonization and infection in very low birth weight infants. J Matern Fetal Neonatal Med. (2015)
  14. ^ a b Suresh Kumar, et al. Evaluation of efficacy of probiotics in prevention of candida colonization in a PICU-a randomized controlled trial. Crit Care Med. (2013)
  15. ^ a b c Hua-Jian Hu, et al. Probiotics Prevent Candida Colonization and Invasive Fungal Sepsis in Preterm Neonates: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pediatr Neonatol. (2017)
  16. ^ Wolfgang Knitsch, et al. A randomized, placebo-controlled trial of preemptive antifungal therapy for the prevention of invasive candidiasis following gastrointestinal surgery for intra-abdominal infections. Clin Infect Dis. (2015)
  17. ^ a b J Xie, et al. Vitamin D-supplemented yogurt drink reduces Candida infections in a paediatric intensive care unit: a randomised, placebo-controlled clinical trial. J Hum Nutr Diet. (2019)
  18. ^ a b Amanda B Arsenault, et al. Dietary Supplementation With Medium-Chain Triglycerides Reduces Candida Gastrointestinal Colonization in Preterm Infants. Pediatr Infect Dis J. (2019)
  19. ^ Anthony P Oyom, et al. Prevalence and antifungal susceptibility of gastrointestinal candidiasis among diabetic patients: A cross-sectional study. Afr J Lab Med. (2020)
  20. ^ Tomasz Gosiewski, et al. Quantitative evaluation of fungi of the genus Candida in the feces of adult patients with type 1 and 2 diabetes - a pilot study. Gut Pathog. (2014)
  21. ^ P L Danna, et al. Role of candida in pathogenesis of antibiotic-associated diarrhoea in elderly inpatients. Lancet. (1991)
  22. ^ a b c Animesh A Mishra, Andrew Y Koh. Adaptation of Candida albicans during gastrointestinal tract colonization. Curr Clin Microbiol Rep. (2018)
  23. ^ A C Mawle, et al. Seroepidemiology of chronic fatigue syndrome: a case-control study. Clin Infect Dis. (1995)
  24. ^ . Candidiasis hypersensitivity syndrome. Executive Committee of the American Academy of Allergy and Immunology. J Allergy Clin Immunol. (1986)
  25. ^ Christel Chehoud, et al. Fungal Signature in the Gut Microbiota of Pediatric Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis. (2015)
  26. ^ M Zwolińska-Wcisło, et al. Are probiotics effective in the treatment of fungal colonization of the gastrointestinal tract? Experimental and clinical studies. J Physiol Pharmacol. (2006)
  27. ^ Piero Sciavilla, et al. Gut microbiota profiles and characterization of cultivable fungal isolates in IBS patients. Appl Microbiol Biotechnol. (2021)
  28. ^ Gaichao Hong, et al. Gut fungal dysbiosis and altered bacterial-fungal interaction in patients with diarrhea-predominant irritable bowel syndrome: An explorative study. Neurogastroenterol Motil. (2020)
  29. ^ a b M Weig, et al. Limited effect of refined carbohydrate dietary supplementation on colonization of the gastrointestinal tract of healthy subjects by Candida albicans. Am J Clin Nutr. (1999)
  30. ^ a b Christian Hoffmann, et al. Archaea and fungi of the human gut microbiome: correlations with diet and bacterial residents. PLoS One. (2013)
  31. ^ R A Hobday, et al. Dietary intervention in chronic fatigue syndrome. J Hum Nutr Diet. (2008)
  32. ^ Narcisa Mandras, et al. The Inhibition of Non- albicans Candida Species and Uncommon Yeast Pathogens by Selected Essential Oils and Their Major Compounds. Molecules. (2021)
  33. ^ Ibrahim Alfarrayeh, et al. Antifungal and Anti-Biofilm Effects of Caffeic Acid Phenethyl Ester on Different Candida Species. Antibiotics (Basel). (2021)
  34. ^ Maria Rejane Cruz de Araújo, et al. Efficacy of essential oil of cinnamon for the treatment of oral candidiasis: A randomized trial. Spec Care Dentist. (2021)