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Insulin Sensitivity

Affects the ability of cells to respond to the hormone insulin. Higher insulin sensitivity indicates better responsiveness, and insulin resistance (low sensitivity) is fundamental for the development of type II diabetes.

Research analysis led by and reviewed by the Examine team.
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Summary of Insulin Sensitivity

Insulin Sensitivity is a function of how well your body can handle glucose (blood sugar) through insulin secretion. Insulin is secreted from an organ called the pancreas in response to elevating blood sugar, and the less insulin that is needed to get the job done is how sensitive you are to insulin.

For a somewhat full review of insulin sensitivity, please refer to our article on increasing insulin sensitivity.

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Insulin Sensitivity.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a - Moderate See all 17 studies
There appears to be highly unreliable evidence for this property for unknown reasons, but chromium may have a role in increasing insulin sensitivity in diabetic persons to a mild degree despite the majority of evidence showing no effects.
grade-a - High See all 12 studies
For the most part, ineffective; too unreliable to reach any conclusions in regards to the efficacy of CLA. There appears to be some manner of interaction, but both sensitization and resistance has been noted
grade-a - Very High See all 12 studies
No significant influence on insulin sensitivity seems to be the consensus, although there are isolated reports of both an increase and decrease (in response to a glucose tolerance test and fasting, respectively)

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