Quick Navigation

Insulin Secretion

Insulin secretion refers to the amount of insulin released from the pancreas either inherently or from a carbohydrate containing test meal. Supplements that increase insulin release are known to be hypoglycemic when taken with a meal.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

Want access to the latest supplement & nutrition info?

Updated with the newest scientific research as it comes in, the Examine.com Membership keeps you informed on over 300 supplements and across over 500 health goals and outcomes. Becoming a member gives you full access to our entire professional database on supplement and nutrition research.

If you are looking for straightforward directions and step-by-step instructions on what works - and what's a waste - to help improve your health, then our Supplement Guides are exactly what you need. Each guide gives you information on what to take, when to take, and how much to take - and all of it is backed by science.

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect insulin secretion
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b - Very High See all 5 studies
There does not appear to be an augmented insulin release from dietary carbohydrate nor an inherent insulin release from the pancreas associated with fish oil supplementation
grade-c Minor - See study
An increase in insulin secretion has been noted with arginine supplementation. This is both due to arginine being a secretagogue (when used acutely), and prolonged usage in those with impaired glucose tolerance may regenerate pancreatic beta-cells
grade-c Minor Moderate See 2 studies
Mixed evidence, but it is possible that chromium causes an increased insulin response to dietary glucose (leading to a greater release of insulin acutely, possibly preceding a reduction in blood glucose).

To view this information, please see the ​Examine.com membership.

The evidence for each separate supplement is still freely available ​here.

grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-c  
grade-d  
grade-d  
grade-d  
grade-d