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Insulin Secretion

Insulin secretion refers to the amount of insulin released from the pancreas either inherently or from a carbohydrate containing test meal. Supplements that increase insulin release are known to be hypoglycemic when taken with a meal.

Kamal
Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect insulin secretion
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Fish Oil - Very High See all 5 studies
There does not appear to be an augmented insulin release from dietary carbohydrate nor an inherent insulin release from the pancreas associated with fish oil supplementation
grade-c Arginine Minor - See study
An increase in insulin secretion has been noted with arginine supplementation. This is both due to arginine being a secretagogue (when used acutely), and prolonged usage in those with impaired glucose tolerance may regenerate pancreatic beta-cells
grade-c Chromium Minor Moderate See 2 studies
Mixed evidence, but it is possible that chromium causes an increased insulin response to dietary glucose (leading to a greater release of insulin acutely, possibly preceding a reduction in blood glucose).
grade-c Cocoa Extract  
grade-c Colostrum  
grade-c Curcumin  
grade-c Green Tea Catechins  
grade-c Inositol  
grade-c Vitamin B3 (Niacin)  
grade-c Vitamin D  
grade-c Creatine  
grade-d Sea Buckthorn  
grade-d Moringa oleifera  
grade-d Pycnogenol  
grade-d Sodium Bicarbonate  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.