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Immunoglobulin M

Research analysis led by Kamal Patel .
Reviewed by
Examine.com Team
Last Updated:

Summary of Immunoglobulin M

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Immunoglobulin M

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect immunoglobulin m.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b - Very High See all 3 studies
IgM does not appear to per se be modified in serum relative to control protein, and unlike the other immunoglobulins there is no augmentation of a vaccine-induced IgM spike.
grade-c Minor - See study
A decrease in IgM concentrations has been noted to occur following supplementation of saffron.
grade-c - - See study
IgM concentrations in the blood of older persons do not appear to be influenced with supplementation of vitamin E.