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Immunoglobulin M

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of Immunoglobulin M

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Immunoglobulin M

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect immunoglobulin m
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b - Very High See all 3 studies
IgM does not appear to per se be modified in serum relative to control protein, and unlike the other immunoglobulins there is no augmentation of a vaccine-induced IgM spike.
grade-c Minor - See study
A decrease in IgM concentrations has been noted to occur following supplementation of saffron.
grade-c - - See study
IgM concentrations in the blood of older persons do not appear to be influenced with supplementation of vitamin E.