Irritable Bowel Syndrome
Summary of Irritable Bowel Syndrome
Primary Information, Benefits, Effects, and Important Facts
Scientific Information on Symptoms of Irritable Bowel Syndrome
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect irritable bowel syndrome.
| Grade | Level of Evidence [show legend] |
|---|---|
|
Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
|
Single double-blind study or multiple cohort studies |
|
Uncontrolled or observational studies only |
|
Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Supplement |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
|
Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
|
Notes |
|---|---|---|---|---|
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Notable
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Very High See all 8 studies |
In persons with IBS, supplementation of peppermint oil appears to reliably and effectively reduce abdominal pain for as long as it is taken. Benefits are no longer seen two weeks after supplement cessation and abdominal pain is the only symptom notably reduced.
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|
|
|
Minor
|
- See study |
One open-label study (lacks blinding for investigators or subjects and no placebo-control) indicated that pynogenol efficacy for IBS symptoms was on par with some of the common pharmacological antispasmodic agents. Although the study design was weak, other studies demonstrating that pycnogenol has a relaxing effect on intestinal smooth muscle tissue lends some increased confidence that it may also be effective as a treatment for IBS.
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