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HDL-C

High Density Lipoprotein Cholesterol (HDL-C) is seen as the 'good' cholesterol (relative to LDL-C). Its job is to bring circulating cholesterol and fatty acids back to the liver tissue and clear them from the blood; high levels are desired to protect the heart.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

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Things To Know & Note

Also Known As

HDL-cholesterol

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect hdl-c
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Notable Very High See all 14 studies
Garlic supplementation tends to increase HDL cholesterol in persons with cardiovascular disease risk reliably and in the range of 10-15% when looking at individual trials and by 1.49mg/dL (95% CI of 0.19-2.79mg/dL) as assessed by meta-analysis.
grade-a Minor Very High See all 27 studies
Mixed evidence, but a possible increase in HDL-C is seen with fish oil supplementation in unhealthy persons
grade-a Minor Moderate See all 12 studies
Unlikely to be potent, either small or no increases in HDL-C are likely to occur after policosanol ingestion. A good deal of the literature is based upon some highly suspicious past research from Cuba
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All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.