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HDL-C

High-density lipoprotein cholesterol (HDL-C) is seen as the “good cholesterol” (relative to LDL-C). Its job is to carry cholesterol and fatty acids from the blood back to the liver. High levels are associated with a lower risk of cardiovascular disease.

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect HDL-C.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Notable Very High See all 14 studies
Garlic supplementation tends to increase HDL cholesterol in persons with cardiovascular disease risk reliably and in the range of 10-15% when looking at individual trials and by 1.49mg/dL (95% CI of 0.19-2.79mg/dL) as assessed by meta-analysis.
grade-a Minor Very High See all 27 studies
Mixed evidence, but a possible increase in HDL-C is seen with fish oil supplementation in unhealthy persons
grade-a Minor Low See all 25 studies
Overall, there appears to be a small increase in HDL, which is more effective in those with obesity and healthy participants as opposed to those with diabetes and kidney disease. There seems to be a greater effect for females but this is only based on a handful of studies.

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Study Deep Dives

Things to Note

Also Known As

HDL-cholesterol