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HbA1c

HbA1c (glycated hemoglobin) is a biomarker of glucose metabolism — it reflects glucose levels over months. Higher HbA1c is associated with more disease progression and comorbidities in states of insulin resistance or diabetes.

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Summary of HbA1c

Hemoglobin A1c (HbA1c) represents the percentage of red blood cells that are glycated (i.e., glucose-bound). HbA1c can give an idea of a person’s average sugar levels over the past 3 months (the approximate lifespan of a red blood cell).

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect HbA1c.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a - Very High See all 18 studies
Although sporadic evidence suggest improvements in HbA1c in diabetics, the entirety of the evidence does not support a reliable and significant improvement in diabetic persons.
grade-a - Moderate See all 10 studies
Although the majority of evidence suggests absolutely no influence on HbA1c, reductions have been reported and a lone case has noted a clinically irrelevant increase of HbA1c (secondary to the increase in glucose). Practically, there is unlikely to be any large changes
grade-b Strong Very High See all 3 studies
The reduction of HbA1c associated with berberine, according to a meta-analysis of diabetics using 1,000-1,500mg berberine daily, was −0.72% (95% CI −0.97 to −0.47) more than placebo. This reduction appears to be one of the more significant reductions associated with dietary supplements.

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