Hemoglobin A1c (HbA1c) represents the percentage of red blood cells that are glycated (i.e., glucose-bound). HbA1c can give an idea of a person’s average sugar levels over the past 3 months (the approximate lifespan of a red blood cell).
HbA1c
Summary of HbA1c
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Human Effect Matrix
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The Human Effect Matrix looks at human studies to tell you what supplements affect HbA1c.
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| Grade | Level of Evidence [show legend] |
|---|---|
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
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Level of Evidence
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The amount of high quality evidence. The more
evidence, the more we can trust the results.
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Supplement |
Magnitude of effect
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The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
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Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
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Notes |
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- | Very High See all 18 studies |
Although sporadic evidence suggest improvements in HbA1c in diabetics, the entirety of the evidence does not support a reliable and significant improvement in diabetic persons.
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- | Moderate See all 10 studies |
Although the majority of evidence suggests absolutely no influence on HbA1c, reductions have been reported and a lone case has noted a clinically irrelevant increase of HbA1c (secondary to the increase in glucose). Practically, there is unlikely to be any large changes
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Strong
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Very High See all 3 studies |
The reduction of HbA1c associated with berberine, according to a meta-analysis of diabetics using 1,000-1,500mg berberine daily, was −0.72% (95% CI −0.97 to −0.47) more than placebo. This reduction appears to be one of the more significant reductions associated with dietary supplements.
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