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Glycemic Control / Insulin Sensitivity

Research analysis led by Kamal Patel .
Reviewed by
Examine.com Team
Last Updated:

Summary of Glycemic Control / Insulin Sensitivity

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Glycemic Control / Insulin Sensitivity

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect glycemic control / insulin sensitivity.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b - Moderate See all 12 studies
An effect is possible in type 2 diabetics but studies are not generally supportive.
grade-c Notable High See all 10 studies
Calculations based on glucose and insulin such as HOMA and QUICKI suggest an improvement in insulin sensitivity on ketogenic diets, even independently of weight loss. One study used a euglycemia hyperinsulinemia clamp and found an improvement in insulin sensitivity, but it was confounded by weight loss.
grade-d - Moderate See 2 studies
One study found a modest improvement only in the 15 ml group and not the 30 ml group, while another didn't note an effect. Much more research is needed to assess the effects of apple cider vinegar, and particularly independently of weight loss.

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