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Follistatin

Follistatin is a molecule that suppresses three protein messengers in the body, one of which is Myostatin; by inhibiting Myostatin's inhibition of protein synthesis, follistatin may increase muscle mass. It may get affected by exercise and diet, but is understudied.

Our evidence-based analysis on follistatin features 34 unique references to scientific papers.

Research analysis led by and reviewed by the Examine team.
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Summary of Follistatin

Follistatin is a negative regulatory protein. It works to regulate the body by suppressing the actions of other proteins and hormones.

When overexpressed, it can cause excessive suppression of these proteins. One of these proteins, Myostatin, is itself a negative regulatory of muscle protein synthesis. Thus, increases in follistatin expression indirectly promote muscle protein synthesis by eliminating a 'lock' on protein synthesis.

Follistatin overexposure (typically though injections) mimics myostatin deficiency, which is colloquially known as 'double muscling' and is the cause of hypermuscularity seen in Belgian Blue Cattle.

Follistatin also has interactions with reproductive health, and may have far-reaching effects due to its suppression of proteins that are not myostatin; namely Activins.

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Follistatin.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-d - - See study
No apparent effect in one study.

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Click here to see all 34 references.