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Edema

Edema is the retention of water in tissue, resulting in weight gain and bloating, and the cause of leg swelling. Some conditions such as diabetics are characterized by edema, and treating the condition may reduce edema.

Kamal
Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect edema
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Centella asiatica Minor Very High See all 5 studies
There appears to be a decrease in edema associated with chronic venous insufficiency (CVI), associated with the treatment of CVI by centella asiatica
grade-c Curcumin Minor - See study
A decrease in edema has been noted with curcumin supplementation
grade-c Methylsulfonylmethane Minor - See study
One study that used MSM as a placebo noted that there was an increase in edema relative to baseline; not known why.
grade-c Serrapeptase  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.