Edema Research Analysis

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect edema

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
Centella asiatica	Minor	Very High See all 5 studies	There appears to be a decrease in edema associated with chronic venous insufficiency (CVI), associated with the treatment of CVI by centella asiatica
Curcumin	Minor	- See study	A decrease in edema has been noted with curcumin supplementation
Methylsulfonylmethane	Minor	- See study	One study that used MSM as a placebo noted that there was an increase in edema relative to baseline; not known why.
Serrapeptase

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.