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DNA Methylation

DNA methylation, which can change the activity of a DNA segment without changing its sequence, has been implicated in aging and disease.

Kamal Patel
Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

Summary of DNA Methylation

Scientific Information on DNA Methylation

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect DNA Methylation.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c
Creatine
Minor - See study
The effect of creatine supplementation on DNA methylation cannot be properly assessed due to a lack of comparisons with other agents.
grade-c
Resveratrol
Minor - See study
A decrease in DNA methylation rates has been noted

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This page is regularly updated, to include the most recently available clinical trial evidence.

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