DHT

Dihydrotestosterone (DHT) is a derivative of testosterone that is known as being more potent at signalling through the androgen receptor, and due to this it is involved to a larger degree in hair loss and prostate cancer.

Our evidence based analysis features 26 unique references to scientific papers.


Research analysis by and verified by the Examine.com Research Team. Last updated on Apr 29, 2017.

Frequently Asked Questions

Questions and answers regarding DHT

Q: Does creatine cause hair loss?

A: It’s plausible, but unlikely. One RCT linked creatine supplementation to an increase in DHT — an androgen involved in hair loss — but this RCT has never been replicated.

Read full answer to "Does creatine cause hair loss?"


Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect dht

Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
Creatine
All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.
The evidence for each separate supplement is still freely available ​here.
Dehydroepiandrosterone  
Fenugreek  
Zinc  
Saw Palmetto  
Boron  

Scientific Support & Reference Citations

Via HEM and FAQ:

  1. van der Merwe J, Brooks NE, Myburgh KH. Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. Clin J Sport Med. (2009)
  2. Kreider RB, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. (2017)
  3. Kaufman KD. Androgens and alopecia. Mol Cell Endocrinol. (2002)
  4. Bang HJ, et al. Comparative studies on level of androgens in hair and plasma with premature male-pattern baldness. J Dermatol Sci. (2004)
  5. Nyholt DR, et al. Genetic basis of male pattern baldness. J Invest Dermatol. (2003)
  6. Rathnayake D, Sinclair R. Male androgenetic alopecia. Expert Opin Pharmacother. (2010)
  7. Bartsch G, Rittmaster RS, Klocker H. Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia. World J Urol. (2002)
  8. Hamada K, Randall VA. Inhibitory autocrine factors produced by the mesenchyme-derived hair follicle dermal papilla may be a key to male pattern baldness. Br J Dermatol. (2006)
  9. Trüeb RM. Molecular mechanisms of androgenetic alopecia. Exp Gerontol. (2002)
  10. Adil A, Godwin M. The effectiveness of treatments for androgenetic alopecia: A systematic review and meta-analysis. J Am Acad Dermatol. (2017)
  11. Redler S, Messenger AG, Betz RC. Genetics and other factors in the aetiology of female pattern hair loss. Exp Dermatol. (2017)
  12. Price VH. Androgenetic alopecia in women. J Investig Dermatol Symp Proc. (2003)
  13. Yip L, Rufaut N, Sinclair R. Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss: an update of what we now know. Australas J Dermatol. (2011)
  14. Green G. Creatine supplementation and DHT:T ratio in male rugby players. Clin J Sport Med. (2010)
  15. Vatani DS, et al. The Effects of Creatine Supplementation on Performance and Hormonal Response in Amateur Swimmers. Science and Sports. (2011)
  16. Arazi H, et al. Effects of short term creatine supplementation and resistance exercises on resting hormonal and cardiovascular responses. Science and Sports. (2015)
  17. Cooke MB, et al. Creatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged males. Eur J Appl Physiol. (2014)
  18. Cook CJ, et al. Skill execution and sleep deprivation: effects of acute caffeine or creatine supplementation - a randomized placebo-controlled trial. J Int Soc Sports Nutr. (2011)
  19. Crowe MJ, O'Connor DM, Lukins JE. The effects of beta-hydroxy-beta-methylbutyrate (HMB) and HMB/creatine supplementation on indices of health in highly trained athletes. Int J Sport Nutr Exerc Metab. (2003)
  20. Hoffman J, et al. Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes. Int J Sport Nutr Exerc Metab. (2006)
  21. Eijnde BO, Hespel P. Short-term creatine supplementation does not alter the hormonal response to resistance training. Med Sci Sports Exerc. (2001)
  22. Volek JS, et al. The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching. Eur J Appl Physiol. (2004)
  23. Faraji H, et al. The effects of creatine supplementation on sprint running performance and selected hormonal responses. SAJRSPER. (2010)
  24. Rahimi R, et al. Creatine supplementation alters the hormonal response to resistance exercise. Kinesiology. (2010)
  25. Volek JS, et al. Response of Testosterone and Cortisol Concentrations to High-Intensity Resistance Exercise Following Creatine Supplementation. JSCR. (1997)
  26. Tyka AK, et al. Effect of creatine malate supplementation on physical performance, body composition and selected hormone levels in spinters and long-distance runners. Acta Physiol Hung. (2015)