Creatinine is a metabolic byproduct of creatine, and is sometimes used as a biomarker for kidney damage as it can accumulate when kidneys are impaired (despite creatine supplementation giving a false positive).

Our evidence-based analysis features 1 unique references to scientific papers.

Research analysis by and verified by the Research Team. Last updated on Apr 29, 2017.

Frequently Asked Questions

Questions and answers regarding Creatinine

Q: Does creatine cause kidney problems?

A: Studies looking at creatine and the kidneys have failed to demonstrate any harm from supplementation (except for some plausible interactions with diuretic pharmaceuticals).

Read full answer to "Does creatine cause kidney problems?"

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect creatinine

Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.
The evidence for each separate supplement is still freely available ​here.
Cissus quadrangularis  
Ginkgo biloba  
Anethum graveolens  
Citrullus colocynthis  
Cocoa Extract  
Eucommia ulmoides  
Green Coffee Extract  
Nigella sativa  
Vitamin E  
Rose Hip  
Bulbine natalensis  
Hibiscus sabdariffa  

Cite this page

"Creatinine,", published on 5 July 2013, last updated on 29 April 2017,