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Cortisol is a hormone that mediates the stress response and sleep-wake cycle, being high in the morning and (hopefully) low in the evening. It triggers gluconeogenesis and a variety of other catabolic reactions. It isn't necessarily harmful or needing to be minimized, but excessive and chronically high cortisol can cause insulin resistance, endothelial dysfunction, reduced immune function, and other negative effects.
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"Cortisol," Examine.com, published on 6 February 2013, last updated on 2 March 2020, https://examine.com/topics/cortisol/