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Colorectal Cancer

Cancer that originates in the colon (large intestine) or rectum (the end of the large intestine closest to the anus).

Our evidence-based analysis on colorectal cancer features 7 unique references to scientific papers.

Research analysis led by and reviewed by the Examine team.
Last Updated:

Summary of Colorectal Cancer

Behind lung cancer, colorectal cancer[1] is the most common cause of cancer death and the fourth most common cancer after lung, breast, and prostate cancer. There were around 1.8 million cases of colorectal cancer worldwide in 2018, resulting in close to 900,000 deaths. Most colorectal cancer cases develop from benign tumors (adenoma) that undergo genetic changes[2] over time (at least 10 years) to ultimately become cancerous (carcinoma). This process, often called the adenoma-carcinoma sequence, is depicted in Figure 1.

Figure 1: The adenoma-carcinoma sequence

Reference: Nguyen et al. Oncol Lett 2018 Jul.[3]

Early detection[4] through colonoscopy screenings is associated with reduced risk of recurrent colorectal cancer and death, and removal of colorectal adenomas appear to reduce the risk of colorectal cancer mortality[5] and incidence[6]. However, recurrence is common[7].

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Colorectal Cancer.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Minor - See study
There appears to be a suppressive effect of reishi ingestion of colorectal adenocarcinomas with prolonged ingestion

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Click here to see all 7 references.