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Cell Adhesion Factors

Cell Adhesion Factors are small targets expressed by blood vessels and organs to attract immune cells (and 'adhere' them to the cell) and draw them into tissue. Suppressing these factors is immunosuppressive, but may alleviate artherosclerosis.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

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Things To Know & Note

Also Known As

sCAM-1, vCAM-1

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect cell adhesion factors
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b
Minor
Low See all 8 studies
Appears to be able to reduce cellular adhesion factors (that draw immune cells into tissue to aid in inflammatory processes, reducing these is immunosuppressive) in elderly persons, while slightly increasing expression in youth
grade-b - High See all 3 studies
While a decrease in P-selectin has been noted with low dose (100mg) γ-tocopherol, most studies have failed to find an influence of vitamin E supplementation on adhesion factors.
grade-c Notable - See study
A decrease was noted in CD40 and MCP1 adhesion factors, and this is notable as this downregulation was dose-dependently related to ingested tyrosol/hydroxytyrosol and may explain the reduced LDL oxidation

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.

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