Quick Navigation

Canker Sores

Canker sore is the common phrase used to refer to small ulcers in the mouth (Aphthous stomatitis), and many anti-ulcer compounds have been tested for their usage against canker sores in reducing inflammation and pain.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect canker sores
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Aloe vera Minor Very High See 2 studies
Appears to be more effective than control, but less effective than the reference drug of 0.1% triamcinolone acetonide
grade-c Berberine Minor - See study
Was able to reduce canker sores when topically applied, but was not compared to a reference compound.
grade-c Lavender Minor - See study
A reduction in canker sore size and the pain associated with them are observed with topical lavender application
grade-c Licorice  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.