Appetite
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Human Effect Matrix
The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect appetite.
| Grade | Level of Evidence [show legend] |
|---|---|
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
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Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Supplement |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
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Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
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Notes |
|---|---|---|---|---|
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Notable
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Very High See all 3 studies |
There does appear to be a fairly effective suppression in appetite noted with 5-HTP supplementation in the higher dosage range, which tends to reduce food intake.
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Minor
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High See all 3 studies |
There may be a role in reducing appetite specifically in persons who self-report inappropriate eating patterns and carbohydrate cravings, with no known effect in persons who do not report such.
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- | Low See all 4 studies |
Variable effects on appetite, but it seems the fenugreek fibers (not commonly in supplements) may reduce appetite similar to most dietary fibers while the saponins (commonly supplemented) have no significant effect or a possible increase
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Get access to the latest nutrition research summarized
By becoming an Examine Plus member, you'll have access to all of the latest nutrition research on over 400 supplements across over 600 different health goals, outcomes, conditions, and more.
Frequently Asked Questions and Articles on Appetite
Propionate – your ally against overeating?
When you eat food, it results in a complex interplay between the food's components, our gut microbiome, and our gut and brain's response. It turns out that a type of fatty acid resulting from this process may help reduce appetite.
Does eating a higher carb diet make you more full?
A study compared real-life high-carb diet versus a high-fat diet and found that a high-carb diet kept you more full (satiated).
Do MCTs or CLA help with appetite reduction?
A recent study investigated if taking MCT or CLA as supplements helped decrease your appetite.
3 Science-based steps to curbing your appetite
Fiber, stress relief, and supplement options can help curb your appetite!
Does chewing gum offer any health benefits?
Chewing gum can provide health benefits ranging from improved oral health to reduced hunger and stress levels, but for some people these are balanced out by possible downsides such as increased headaches.
The science behind munchies: cannabis and your appetite
Tetrahydrocannabinol (THC), a cannabinoid in cannabis, can bind the cannabinoid receptor type 1 (CB1) and thus promote overeating and weight gain. This effect, detrimental to most people, can prove beneficial under certain medical conditions, such as cancer and HIV-associated wasting syndrome.
Does Garcinia Cambogia help with weight loss?
Garcinia Cambogia does not appear to help with weight loss in humans despite its popularity, and this is due to a profound difference in how it affects rats and humans.
Does aspartame increase appetite?
Click here to see all 105 references.
