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AMP-activated protein kinase (AMPK)

AMPK is an enzyme that plays a central role in regulating energy homeostasis. In response to low energy levels or metabolic stress, it phosphorylates other proteins to limit ATP consumption and increase ATP synthesis.

Our evidence-based analysis on amp-activated protein kinase (ampk) features 14 unique references to scientific papers.

Research analysis led by and reviewed by the Examine team.
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References

  1. ^ a b Joungmok Kim, et al. AMPK activators: mechanisms of action and physiological activities. Exp Mol Med. (2016)
  2. ^ S L Choi, et al. The regulation of AMP-activated protein kinase by H(2)O(2). Biochem Biophys Res Commun. (2001)
  3. ^ G C Gaitanos, et al. Human muscle metabolism during intermittent maximal exercise. J Appl Physiol (1985). (1993)
  4. ^ Dana M Gwinn, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. (2008)
  5. ^ L Deldicque, D Theisen, M Francaux. Regulation of mTOR by amino acids and resistance exercise in skeletal muscle. Eur J Appl Physiol. (2005)
  6. ^ Eva Masiero, et al. Autophagy is required to maintain muscle mass. Cell Metab. (2009)
  7. ^ Ping Li, et al. Autophagy and Aging: Roles in Skeletal Muscle, Eye, Brain and Hepatic Tissue. Front Cell Dev Biol. (2021)
  8. ^ Grace Y Liu, David M Sabatini. mTOR at the nexus of nutrition, growth, ageing and disease. Nat Rev Mol Cell Biol. (2020)
  9. ^ Zhou G, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. (2001)
  10. ^ Chang Eun Park, et al. Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Exp Mol Med. (2007)
  11. ^ Jiyun Ahn, et al. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem Biophys Res Commun. (2008)
  12. ^ a b Jin-Taek Hwang, et al. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem Biophys Res Commun. (2005)
  13. ^ Yun S Lee, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes. (2006)
  14. ^ Woo Je Lee, et al. Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun. (2005)