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Alcohol Dependence

Kamal Patel
Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Summary of Alcohol Dependence

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Alcohol Dependence

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect alcohol dependence
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c
L-Carnitine
Minor - See study
A reduced rate of relapse and alcohol cravings was noted with ALCAR ingestion relative to placebo
grade-c
Modafinil
Minor - See study
Alcohol dependence, particularly the impulsivity thereof, appears to be slightly reduced with modafinil administration
grade-c
Yohimbine
Minor - See study
Injections of yohimbine have been noted to increase cravings for alcohol, which although not demonstrated with oral intake is thought to be related to the reduction in inhibition

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.

This page is regularly updated, to include the most recently available clinical trial evidence.

Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. We have a strict editorial process.

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