Alcohol Dependence Research Analysis

Summary of Alcohol Dependence

Scientific Information on Alcohol Dependence

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect alcohol dependence

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
L-Carnitine	Minor	- See study	A reduced rate of relapse and alcohol cravings was noted with ALCAR ingestion relative to placebo
Modafinil	Minor	- See study	Alcohol dependence, particularly the impulsivity thereof, appears to be slightly reduced with modafinil administration
Yohimbine	Minor	- See study	Injections of yohimbine have been noted to increase cravings for alcohol, which although not demonstrated with oral intake is thought to be related to the reduction in inhibition

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.