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Advanced Glycation End Products

Advanced glycation end products (AGEs) are highly reactive compounds that result from chemical reactions in the body. While their formation is a byproduct of normal metabolism, a growing body of evidence suggest they may be linked with many chronic diseases.

Our evidence-based analysis on advanced glycation end products features 5 unique references to scientific papers.

Research analysis led by and reviewed by the Examine team.
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Summary of Advanced Glycation End Products

Advanced glycation end products (AGEs) are highly reactive compounds that result from a chemical reaction between reducing sugars and amino acids (also known as a Maillard reaction) and from the oxidation of sugars, lipids, and amino acids. Although the formation of AGEs within the body is a part of normal metabolism, a growing body of evidence[1][2][3] suggests that excessive AGE levels promote oxidative stress and inflammation and may therefore increase the risk of developing type 2 diabetes, cardiovascular disease, fatty liver, cancer, Alzheimer’s disease, and infertility.

AGEs were first recognized as being produced within the body under conditions of increased oxidative stress. However, it is now known that dietary AGEs are important contributors[4] to the body’s total AGE concentration, where they become indistinguishable[5] from those AGEs produced within the body itself. The most widely studied AGE is carboxymethyllysine (CML), while another common marker of AGE formation is methyl-glyoxal (MG).

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Human Effect Matrix

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The Human Effect Matrix looks at human studies to tell you what supplements affect Advanced Glycation End Products.

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Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Supplement Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c - - See study
No significant changes in urinary or serum AGEs observed at the moment
grade-d - - See study

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Study Deep Dives

Things to Note

Also Known As

AGEs

Click here to see all 5 references.