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Adrenaline is a catecholamine that mediates the 'fight or flight' response, and also possesses fat burning properties. Increases in serum adrenaline are known to improve focus and fat oxidation, and supplements that increase adrenaline are thought to retain these effects.

Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect adrenaline
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Caffeine Minor Very High See all 3 studies
Serum catecholamines (adrenaline, noradrenaline) are increased in naive users of caffeine following acute ingestion
grade-b Melatonin - Very High See all 4 studies
There do not appear to be any influence of melatonin ingestion on plasma adrenaline, either inherently or from influencing the spike in adrenaline from stress
grade-c Cocoa Extract Minor Moderate See 2 studies
Mixed evidence as to whether serum adrenaline can be reduced in serum following cocoa ingestion prior to an acute stressor.
grade-c Mucuna pruriens  
grade-c Alcohol  
grade-c Branched Chain Amino Acids  
grade-c Creatine  
grade-c Ganoderma lucidum  
grade-c Sodium Bicarbonate  
grade-d Vitamin B3 (Niacin)  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.