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Adaptations to Exercise

Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Summary of Adaptations to Exercise

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Adaptations to Exercise

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect adaptations to exercise
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The mo re evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Resveratrol Notable - See study
Supplementation of resveratrol before exercise can fairly effectively prevent the benefits associated with intense exercise (increases in oxygen capacity and HDL-C, reductions in LDL-C and blood pressure) in otherwise healthy men. Theoretically, the mTOR inhibition of resveratrol may also inhibit muscle protein synthesis.
grade-c Vitamin C Minor Moderate See 2 studies
It is thought that, secondary to reducing the rate of muscular damage, that adaptations gained from exercise are attenuated; there is mixed evidence to support this, but is seems possible with antioxidants

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.