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Alzheimer’s disease (AD)

AD is a neurodegenerative disease. In a person with AD, cognitive decline and functional impairment are much more severe than can be explained by just the person’s age.

Our evidence-based analysis on alzheimer’s disease (ad) features 18 unique references to scientific papers.

Research analysis led by and reviewed by the Examine team.
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References

  1. ^ . 2021 Alzheimer's disease facts and figures. Alzheimers Dement. (2021)
  2. ^ M Paul Murphy, Harry LeVine 3rd. Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis. (2010)
  3. ^ Michael A Castello, Salvador Soriano. On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis. Ageing Res Rev. (2014)
  4. ^ Li-Kai Huang, Shu-Ping Chao, Chaur-Jong Hu. Clinical trials of new drugs for Alzheimer disease. J Biomed Sci. (2020)
  5. ^ Konstantina G Yiannopoulou, et al. Reasons for Failed Trials of Disease-Modifying Treatments for Alzheimer Disease and Their Contribution in Recent Research. Biomedicines. (2019)
  6. ^ Suélen Santos Alves, et al. Insulin Resistance as a Common Link Between Current Alzheimer's Disease Hypotheses. J Alzheimers Dis. (2021)
  7. ^ Uday Saxena. Alzheimer's disease amyloid hypothesis at crossroads: where do we go from here?. Expert Opin Ther Targets. (2010)
  8. ^ Athanasios Metaxas, Stefan J Kempf. Neurofibrillary tangles in Alzheimer's disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics. Neural Regen Res. (2016)
  9. ^ Lisa Mosconi, Alberto Pupi, Mony J De Leon. Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann N Y Acad Sci. (2008)
  10. ^ Suzanne M de la Monte, Jack R Wands. Alzheimer's disease is type 3 diabetes-evidence reviewed. J Diabetes Sci Technol. (2008)
  11. ^ Yuri Zilberter, Misha Zilberter. The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction. J Neurosci Res. (2017)
  12. ^ Jill K Morris, et al. Impaired glycemia increases disease progression in mild cognitive impairment. Neurobiol Aging. (2014)
  13. ^ Paul K Crane, et al. Glucose levels and risk of dementia. N Engl J Med. (2013)
  14. ^ Takako Niikura, Hirohisa Tajima, Yoshiko Kita. Neuronal cell death in Alzheimer's disease and a neuroprotective factor, humanin. Curr Neuropharmacol. (2006)
  15. ^ Natalia García-Casares, et al. Alzheimer's Disease, Mild Cognitive Impairment and Mediterranean Diet. A Systematic Review and Dose-Response Meta-Analysis. J Clin Med. (2021)
  16. ^ Matthew K Taylor, et al. High Glycemic Diet Is Related to Brain Amyloid Accumulation Over One Year in Preclinical Alzheimer's Disease. Front Nutr. (2021)
  17. ^ Silvia Duong, Tejal Patel, Feng Chang. Dementia: What pharmacists need to know. Can Pharm J (Ott). (2017)
  18. ^ David B Hogan, et al. The Prevalence and Incidence of Frontotemporal Dementia: a Systematic Review. Can J Neurol Sci. (2016)