The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect acne.
| Grade | Level of Evidence [show legend] |
|---|---|
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Robust research conducted with repeated double-blind clinical trials |
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Multiple studies where at least two are double-blind and placebo controlled |
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Single double-blind study or multiple cohort studies |
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Uncontrolled or observational studies only |
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Level of Evidence
?
The amount of high quality evidence. The more
evidence, the more we can trust the results.
|
Supplement |
Magnitude of effect
?
The direction and size of the supplement's impact on
each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
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Consistency of research results
?
Scientific research does not always agree. HIGH or
VERY HIGH means that most of the scientific research agrees.
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Notes |
|---|---|---|---|---|
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Notable
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Very High See all 3 studies |
Topical application of 4% nicotinamide gel rivals 1% clindamycin gel in reducing acne severity and tends to work better than clindamycin in oily skin types.
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Minor
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Very High See all 4 studies |
Orally supplemented zinc (in the dosage range of 30-130mg elemental zinc) appears to be effective in reducing symptoms of acne, although the effects are modest at best.
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- | - See study |
One study assessing the blinded intake of chocolate in subjects who reported to be acne prone found an increase in acne when chocolate was given relative to placebo.
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