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Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of 8-isoPGF2a

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on 8-isoPGF2a

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect 8-isopgf2a
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Minor Moderate See all 4 studies
This biomarker of inflammation has been noted to be reduced in two studies where the subjects were prooxidative at rest (PAD and smokers), with no influence in other studies of otherwise healthy subjects.
grade-c Minor Very High See all 3 studies
8-isoPGF(2)a is normally a biomarker of lipid peroxidation, but CLA may be causing a false positive (as fatty acids are known to interact with the enzymes in question and other markers of lipid peroxidation are unchanged).
grade-c - - See study
Urinary 8-isoPGF2α is unchanged with prolonged quercetin supplementation.