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Senna alexandrina

Senna Alexandria is a plant containing Sennosides, which are laxatives. Nothing more special about Senna root or Sennosides, they just are very effective at clearing your bowels and are at a level of potency where they are sometimes given before a colonoscopy.

Our evidence-based analysis on senna alexandrina features 41 unique references to scientific papers.

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How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

In accordance with clinical usage, the correct dose is the "lowest dose required to produce the desired effects (soft-formed and comfortable stool)". This is either 1-2g of the powdered extract or fruit usually standardized to 10-30mg active Sennosides.

Higher doses are used only if the aforementioned lower dose is not effective (it should be noted that senna alexandria is a delayed laxative unlike the immediate effects of caffeine and it may take a few hours to assess whether a dose is effective or not).

Senna alexandria tends to be taken prior to bed in order to time its laxative effect with a morning bowel movement.

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Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix summarizes human studies to tell you what effects Senna alexandrina has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Strong Very High See all 6 studies
Due to the strong laxative effect, constipation is greatly reduced with supplemental Senna Alexandria. Has been noted effective against regular, postpartum, and opioid-induced constipation and appears to not require a context-specific cause of constipation (ie. reliable) but appears to be associated with more cramping than placebo.
grade-b Strong Very High See all 10 studies
Senna Alexandria is a reference drug for its laxative effects, with comparable efficacy to oral polyethylene glycol (PEG; used before colonoscopies) and lactulose, but more cost-effective than the latter

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Things to Note

Is a Form Of

Primary Function:

Also Known As

Senna alexandrina, Daio

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Click here to see all 41 references.