Piceatannol

Last Updated: September 28 2022

Piceatannol is a stilbene similar to resveratrol that is found in limited levels in some of the same foods. They share many properties, and while piceatannol may be a possible alternative there is not enough evidence to suggest it is better than resveratrol.

Piceatannol is most often used for

What else is Piceatannol known as?
Note that Piceatannol is also known as:
  • Astringinin
Piceatannol should not be confused with:

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References
1.^Rimando AM, Kalt W, Magee JB, Dewey J, Ballington JRResveratrol, pterostilbene, and piceatannol in vaccinium berriesJ Agric Food Chem.(2004 Jul 28)
3.^Piotrowska H, Kucinska M, Murias MBiological activity of piceatannol: leaving the shadow of resveratrolMutat Res.(2012 Jan-Mar)
4.^Cantos E, Espín JC, Fernández MJ, Oliva J, Tomás-Barberán FAPostharvest UV-C-irradiated grapes as a potential source for producing stilbene-enriched red winesJ Agric Food Chem.(2003 Feb 26)
5.^Guerrero RF, Puertas B, Jiménez MJ, Cacho J, Cantos-Villar EThe occurrence of the stilbene piceatannol in grapesFood Chem.(2010 Sep)
6.^Buiarelli F, Coccioli F, Jasionowska R, Merolle M, Terracciano AAnalysis of some stilbenes in Italian wines by liquid chromatography/tandem mass spectrometryRapid Commun Mass Spectrom.(2007)
7.^Guerrero RF, Puertas B, Jiménez MJ, Cacho J, Cantos-Villar EMonitoring the process to obtain red wine enriched in resveratrol and piceatannol without quality lossFood Chem.(2010 Sep)
8.^Boutegrabet L, Fekete A, Hertkorn N, Papastamoulis Y, Waffo-Téguo P, Mérillon JM, Jeandet P, Gougeon RD, Schmitt-Kopplin PDetermination of stilbene derivatives in Burgundy red wines by ultra-high-pressure liquid chromatographyAnal Bioanal Chem.(2011 Sep)
10.^Matsui Y, Sugiyama K, Kamei M, Takahashi T, Suzuki T, Katagata Y, Ito TExtract of Passion Fruit ( Passiflora edulis ) Seed Containing High Amounts of Piceatannol Inhibits Melanogenesis and Promotes Collagen SynthesisJ Agric Food Chem.(2010 Sep 7)
11.^Maruki-Uchida H, Kurita I, Sugiyama K, Sai M, Maeda K, Ito TThe protective effects of piceatannol from passion fruit (Passiflora edulis) seeds in UVB-irradiated keratinocytesBiol Pharm Bull.(2013)
13.^Ko SKA new stilbene diglycoside from Rheum undulatumArch Pharm Res.(2000 Apr)
16.^Adesanya SA, Nia R, Martin MT, Boukamcha N, Montagnac A, Païs MStilbene Derivatives from Cissus quadrangularisJ Nat Prod.(1999 Oct)
17.^Benová B, Adam M, Onderková K, Královský J, Krajícek MAnalysis of selected stilbenes in Polygonum cuspidatum by HPLC coupled with CoulArray detectionJ Sep Sci.(2008 Jul)
18.^Vastano BC, Chen Y, Zhu N, Ho CT, Zhou Z, Rosen RTIsolation and identification of stilbenes in two varieties of Polygonum cuspidatumJ Agric Food Chem.(2000 Feb)
20.^Baez DA, Vallejo LGZ, Jiminez-Estrada MPhytochemical Studies On Senna Skinneri and Senna WislizeniNat Prod Lett.(1999)
22.^Choi KH, Kim JE, Song NR, Son JE, Hwang MK, Byun S, Kim JH, Lee KW, Lee HJPhosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cellsCardiovasc Res.(2010 Mar 1)
23.^Lee CK, Lee HM, Kim HJ, Park HJ, Won KJ, Roh HY, Choi WS, Jeon BH, Park TK, Kim BSyk contributes to PDGF-BB-mediated migration of rat aortic smooth muscle cells via MAPK pathwaysCardiovasc Res.(2007 Apr 1)
24.^Oliver JM, Burg DL, Wilson BS, McLaughlin JL, Geahlen RLInhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannolJ Biol Chem.(1994 Nov 25)
27.^Murias M, Handler N, Erker T, Pleban K, Ecker G, Saiko P, Szekeres T, Jäger WResveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationshipBioorg Med Chem.(2004 Nov 1)
28.^Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, Gildehaus D, Miyashiro JM, Penning TD, Seibert K, Isakson PC, Stallings WCStructural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agentsNature.(1996 Dec 19-26)
30.^Gledhill JR, Montgomery MG, Leslie AG, Walker JEMechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenolsProc Natl Acad Sci U S A.(2007 Aug 21)
32.^Dickson VK, Silvester JA, Fearnley IM, Leslie AG, Walker JEOn the structure of the stator of the mitochondrial ATP synthaseEMBO J.(2006 Jun 21)
33.^Senior AE, Nadanaciva S, Weber JThe molecular mechanism of ATP synthesis by F1F0-ATP synthaseBiochim Biophys Acta.(2002 Feb 15)
37.^Almeida MR, Gales L, Damas AM, Cardoso I, Saraiva MJSmall transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidosesCurr Drug Targets CNS Neurol Disord.(2005 Oct)
38.^Roupe KA, Yáñez JA, Teng XW, Davies NMPharmacokinetics of selected stilbenes: rhapontigenin, piceatannol and pinosylvin in ratsJ Pharm Pharmacol.(2006 Nov)
40.^Potter GA, Patterson LH, Wanogho E, Perry PJ, Butler PC, Ijaz T, Ruparelia KC, Lamb JH, Farmer PB, Stanley LA, Burke MDThe cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1Br J Cancer.(2002 Mar 4)
42.^Piver B, Fer M, Vitrac X, Merillon JM, Dreano Y, Berthou F, Lucas DInvolvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomesBiochem Pharmacol.(2004 Aug 15)
44.^Niles RM, Cook CP, Meadows GG, Fu YM, McLaughlin JL, Rankin GOResveratrol is rapidly metabolized in athymic (nu/nu) mice and does not inhibit human melanoma xenograft tumor growthJ Nutr.(2006 Oct)
45.^Miksits M, Sulyok M, Schuhmacher R, Szekeres T, Jäger WIn-vitro sulfation of piceatannol by human liver cytosol and recombinant sulfotransferasesJ Pharm Pharmacol.(2009 Feb)
46.^Miksits M, Maier-Salamon A, Vo TP, Sulyok M, Schuhmacher R, Szekeres T, Jäger WGlucuronidation of piceatannol by human liver microsomes: major role of UGT1A1, UGT1A8 and UGT1A10J Pharm Pharmacol.(2010 Jan)
47.^Mikstacka R, Rimando AM, Szalaty K, Stasik K, Baer-Dubowska WEffect of natural analogues of trans-resveratrol on cytochromes P4501A2 and 2E1 catalytic activitiesXenobiotica.(2006 Apr)
48.^Mikstacka R, Gnojkowski J, Baer-Dubowska WEffect of natural phenols on the catalytic activity of cytochrome P450 2E1Acta Biochim Pol.(2002)
49.^Hsieh TC, Bennett DJ, Lee YS, Wu E, Wu JMIn silico and biochemical analyses identify quinone reductase 2 as a target of piceatannolCurr Med Chem.(2013)
50.^Zhang S, Yang L, Kouadir M, Tan R, Lu Y, Chang J, Xu B, Yin X, Zhou X, Zhao DPP2 and piceatannol inhibit PrP106-126-induced iNOS activation mediated by CD36 in BV2 microgliaActa Biochim Biophys Sin (Shanghai).(2013 Sep)
51.^Forloni G, Angeretti N, Chiesa R, Monzani E, Salmona M, Bugiani O, Tagliavini FNeurotoxicity of a prion protein fragmentNature.(1993 Apr 8)
52.^Aguzzi A, Heikenwalder MPathogenesis of prion diseases: current status and future outlookNat Rev Microbiol.(2006 Oct)
53.^Kouadir M, Yang L, Tan R, Shi F, Lu Y, Zhang S, Yin X, Zhou X, Zhao DCD36 participates in PrP(106-126)-induced activation of microgliaPLoS One.(2012)
57.^Yoo MY, Oh KS, Lee JW, Seo HW, Yon GH, Kwon DY, Kim YS, Ryu SY, Lee BHVasorelaxant effect of stilbenes from rhizome extract of rhubarb (Rheum undulatum) on the contractility of rat aortaPhytother Res.(2007 Feb)
58.^Lee HM, Kim HJ, Park HJ, Won KJ, Kim J, Shin HS, Park PJ, Kim HJ, Lee KY, Park SH, Lee CK, Kim BSpleen tyrosine kinase participates in Src-mediated migration and proliferation by PDGF-BB in rat aortic smooth muscle cellsArch Pharm Res.(2007 Jun)
59.^Raines EWPDGF and cardiovascular diseaseCytokine Growth Factor Rev.(2004 Aug)
60.^Ross RAtherosclerosis--an inflammatory diseaseN Engl J Med.(1999 Jan 14)
62.^Berkowitz DE, White R, Li D, Minhas KM, Cernetich A, Kim S, Burke S, Shoukas AA, Nyhan D, Champion HC, Hare JMArginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vesselsCirculation.(2003 Oct 21)
63.^Simon A, Plies L, Habermeier A, Martiné U, Reining M, Closs EIRole of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cellsCirc Res.(2003 Oct 31)
65.^Nelin LD, Wang X, Zhao Q, Chicoine LG, Young TL, Hatch DM, English BK, Liu YMKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challengeAm J Physiol Cell Physiol.(2007 Aug)
66.^Ryoo S, Lemmon CA, Soucy KG, Gupta G, White AR, Nyhan D, Shoukas A, Romer LH, Berkowitz DEOxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signalingCirc Res.(2006 Oct 27)
67.^Que LG, Kantrow SP, Jenkinson CP, Piantadosi CA, Huang YCInduction of arginase isoforms in the lung during hyperoxiaAm J Physiol.(1998 Jul)
71.^MacAllister RJ, Parry H, Kimoto M, Ogawa T, Russell RJ, Hodson H, Whitley GS, Vallance PRegulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolaseBr J Pharmacol.(1996 Dec)
72.^Chen Y, Li Y, Zhang P, Traverse JH, Hou M, Xu X, Kimoto M, Bache RJDimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing heartsAm J Physiol Heart Circ Physiol.(2005 Nov)
73.^Bełtowski J, Kedra AAsymmetric dimethylarginine (ADMA) as a target for pharmacotherapyPharmacol Rep.(2006 Mar-Apr)
75.^Murias M, Jäger W, Handler N, Erker T, Horvath Z, Szekeres T, Nohl H, Gille LAntioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure-activity relationshipBiochem Pharmacol.(2005 Mar 15)
76.^Kinoshita Y, Kawakami S, Yanae K, Sano S, Uchida H, Inagaki H, Ito TEffect of long-term piceatannol treatment on eNOS levels in cultured endothelial cellsBiochem Biophys Res Commun.(2013 Jan 18)
77.^Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WCRegulation of endothelium-derived nitric oxide production by the protein kinase AktNature.(1999 Jun 10)
79.^Maggiolini M, Recchia AG, Bonofiglio D, Catalano S, Vivacqua A, Carpino A, Rago V, Rossi R, Andò SThe red wine phenolics piceatannol and myricetin act as agonists for estrogen receptor alpha in human breast cancer cellsJ Mol Endocrinol.(2005 Oct)
83.^Drábiková K, Perečko T, Nosáľ R, Harmatha J, Smidrkal J, Jančinová VPolyphenol derivatives - potential regulators of neutrophil activityInterdiscip Toxicol.(2012 Jun)
84.^Kalariya NM, Shoeb M, Reddy AB, Sawhney R, Ramana KVPiceatannol suppresses endotoxin-induced ocular inflammation in ratsInt Immunopharmacol.(2013 Oct)
85.^Nussenblatt RBThe natural history of uveitisInt Ophthalmol.(1990 Oct)
86.^Gajjar K, Martin-Hirsch PL, Martin FLCYP1B1 and hormone-induced cancerCancer Lett.(2012 Nov 1)
87.^Agundez JACytochrome P450 gene polymorphism and cancerCurr Drug Metab.(2004 Jun)
88.^McFadyen MC, Murray GICytochrome P450 1B1: a novel anticancer therapeutic targetFuture Oncol.(2005 Apr)
89.^Buharalioglu CK, Song CY, Yaghini FA, Ghafoor HU, Motiwala M, Adris T, Estes AM, Malik KUAngiotensin II-induced process of angiogenesis is mediated by spleen tyrosine kinase via VEGF receptor-1 phosphorylationAm J Physiol Heart Circ Physiol.(2011 Sep)
95.^Grell M, Douni E, Wajant H, Löhden M, Clauss M, Maxeiner B, Georgopoulos S, Lesslauer W, Kollias G, Pfizenmaier K, Scheurich PThe transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptorCell.(1995 Dec 1)
96.^Mochizuki S, Okada YADAMs in cancer cell proliferation and progressionCancer Sci.(2007 May)
99.^Szalad A, Katakowski M, Zheng X, Jiang F, Chopp MTranscription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxiaJ Exp Clin Cancer Res.(2009 Sep 22)
100.^Elcheva I1, Goswami S, Noubissi FK, Spiegelman VSCRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradationMol Cell.(2009 Jul 31)
103.^Kang CH, Moon DO, Choi YH, Choi IW, Moon SK, Kim WJ, Kim GYPiceatannol enhances TRAIL-induced apoptosis in human leukemia THP-1 cells through Sp1- and ERK-dependent DR5 up-regulationToxicol In Vitro.(2011 Apr)
104.^Fritzer-Szekeres M, Savinc I, Horvath Z, Saiko P, Pemberger M, Graser G, Bernhaus A, Ozsvar-Kozma M, Grusch M, Jaeger W, Szekeres TBiochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells--synergism with Ara-CInt J Oncol.(2008 Oct)
106.^Lasham A, Lindridge E, Rudert F, Onrust R, Watson JRegulation of the human fas promoter by YB-1, Purα and AP-1 transcription factorsGene.(2000 Jul)
107.^Thorburn ADeath receptor-induced cell killingCell Signal.(2004 Feb)
108.^Yokozawa T, Kim YJPiceatannol inhibits melanogenesis by its antioxidative actionsBiol Pharm Bull.(2007 Nov)
110.^Pepys MBAmyloidosisAnnu Rev Med.(2006)
112.^Costa R, Gonçalves A, Saraiva MJ, Cardoso ITransthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicityFEBS Lett.(2008 Mar 19)
113.^Han YS, Bastianetto S, Dumont Y, Quirion RSpecific plasma membrane binding sites for polyphenols, including resveratrol, in the rat brainJ Pharmacol Exp Ther.(2006 Jul)