Oxaloacetate

Last Updated: September 28 2022

Oxaloacetate is an intermediate of the Kreb's cycle that binds to acetyl-CoA in the formation of citrate. A depletion of oxaloacetate relative to acetyl-CoA is the key step for the production of ketone bodies within the liver.

Oxaloacetate is most often used for

What else is Oxaloacetate known as?
Note that Oxaloacetate is also known as:
  • OAA
  • 3-carboxy-3-oxopropanoic acid

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References
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2.^Passarella S, Barile M, Atlante A, Quagliariello EOxaloacetate uptake into rat brain mitochondria and reconstruction of the malate/oxaloacetate shuttleBiochem Biophys Res Commun.(1984 Mar 30)
3.^Passarella S, Atlante A, Quagliariello EOxaloacetate permeation in rat kidney mitochondria: pyruvate/oxaloacetate and malate/oxaloacetate translocatorsBiochem Biophys Res Commun.(1985 May 31)
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7.^Zlotnik A1, Sinelnikov I, Gruenbaum BF, Gruenbaum SE, Dubilet M, Dubilet E, Leibowitz A, Ohayon S, Regev A, Boyko M, Shapira Y, Teichberg VIEffect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in ratsAnesthesiology.(2012 Jan)
8.^Wilkins HM1, Harris JL2, Carl SM3, E L4, Lu J5, Eva Selfridge J6, Roy N6, Hutfles L3, Koppel S3, Morris J1, Burns JM7, Michaelis ML8, Michaelis EK8, Brooks WM9, Swerdlow RH10Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesisHum Mol Genet.(2014 Jul 15)
11.^Chen D1, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente LTissue-specific regulation of SIRT1 by calorie restrictionGenes Dev.(2008 Jul 1)
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