Last Updated: September 28 2022

Oxaloacetate is an intermediate of the Kreb's cycle that binds to acetyl-CoA in the formation of citrate. A depletion of oxaloacetate relative to acetyl-CoA is the key step for the production of ketone bodies within the liver.

Oxaloacetate is most often used for

What else is Oxaloacetate known as?
Note that Oxaloacetate is also known as:
  • OAA
  • 3-carboxy-3-oxopropanoic acid

Don't miss out on the latest research

1.^Strong R1, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DEEvaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous miceJ Gerontol A Biol Sci Med Sci.(2013 Jan)
2.^Passarella S, Barile M, Atlante A, Quagliariello EOxaloacetate uptake into rat brain mitochondria and reconstruction of the malate/oxaloacetate shuttleBiochem Biophys Res Commun.(1984 Mar 30)
3.^Passarella S, Atlante A, Quagliariello EOxaloacetate permeation in rat kidney mitochondria: pyruvate/oxaloacetate and malate/oxaloacetate translocatorsBiochem Biophys Res Commun.(1985 May 31)
4.^Zlotnik A1, Gruenbaum SE, Artru AA, Rozet I, Dubilet M, Tkachov S, Brotfain E, Klin Y, Shapira Y, Teichberg VIThe neuroprotective effects of oxaloacetate in closed head injury in rats is mediated by its blood glutamate scavenging activity: evidence from the use of maleateJ Neurosurg Anesthesiol.(2009 Jul)
5.^Zlotnik A1, Gurevich B, Cherniavsky E, Tkachov S, Matuzani-Ruban A, Leon A, Shapira Y, Teichberg VIThe contribution of the blood glutamate scavenging activity of pyruvate to its neuroprotective properties in a rat model of closed head injuryNeurochem Res.(2008 Jun)
6.^Gottlieb M1, Wang Y, Teichberg VIBlood-mediated scavenging of cerebrospinal fluid glutamateJ Neurochem.(2003 Oct)
7.^Zlotnik A1, Sinelnikov I, Gruenbaum BF, Gruenbaum SE, Dubilet M, Dubilet E, Leibowitz A, Ohayon S, Regev A, Boyko M, Shapira Y, Teichberg VIEffect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in ratsAnesthesiology.(2012 Jan)
8.^Wilkins HM1, Harris JL2, Carl SM3, E L4, Lu J5, Eva Selfridge J6, Roy N6, Hutfles L3, Koppel S3, Morris J1, Burns JM7, Michaelis ML8, Michaelis EK8, Brooks WM9, Swerdlow RH10Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesisHum Mol Genet.(2014 Jul 15)
11.^Chen D1, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente LTissue-specific regulation of SIRT1 by calorie restrictionGenes Dev.(2008 Jul 1)
12.^Braeckman BP1, Houthoofd K, Vanfleteren JRIntermediary metabolismWormBook.(2009 Feb 16:1-24)
14.^Edwards CB1, Copes N, Brito AG, Canfield J, Bradshaw PCMalate and fumarate extend lifespan in Caenorhabditis elegansPLoS One.(2013)
15.^Rafaeloff-Phail R1, Ding L, Conner L, Yeh WK, McClure D, Guo H, Emerson K, Brooks HBiochemical regulation of mammalian AMP-activated protein kinase activity by NAD and NADHJ Biol Chem.(2004 Dec 17)