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MitoQ

MitoQ (mitoquinone mesylate) is a derivative of CoQ10 believed to play a role in mitochondrial function, but without much supporting evidence.

Our evidence-based analysis on mitoq features 9 unique references to scientific papers.

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Things To Know & Note

Also Known As

{10-(4, 5-dimethoxy-2-methyl-3, 6-dioxo-1, 4-cycloheexadienlyl) decyl triphenylphosphonium methanesulfonate}, mitoquinone mesylate

Do Not Confuse With

CoQ10 (parent molecule), Idebenone (another derivative)

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Scientific Research on MitoQ

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MitoQ is a term used to refer to mitoquinone mesylate ( with {10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cycloheexadienlyl) decyl triphenylphosphonium methanesulfonate}) as the prolonged chemical name), which is a derivative of CoQ10 where said molecule is covalently bonded to a triphenylphosphonium cation.

The CoQ10 moiety is delivered to the matrix side of the inner mitochondrial matrix,[1] which is the site of most mitochondrial oxidative stress.[2] Despite accumulation in the mitrochondria, however, MitoQ is a poor substrate for the electron transport chain (at complex I) and is not thought to contribute much to bioenergetics.[3][4]

Oral administration of MitoQ in otherwise healthy wild type mice over 28 weeks fails to significantly alter mitochondrial function or gene expression, and no overall influence on systemic energy metabolism.[5]

Alzheimer's is known to be associated with mitochondrial abnormalities in neurons associated with oxidative stress[6][7]

Beta-amyloid toxicity has been noted to be reduced in N2a cells with MitoQ incubation[8] and at 1-100nM mostly abolished cell death from amyloid proteins (no dose dependence noted).[9]

100μM of MitoQ daily to a mouse model of Alzheimer's has been noted to improve spatial memory and cognitive performance associated with a reduction in lipid peroxidation.[9]