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Glycine

Glycine is an amino acid and neurotransmitter. It can play both stimulatory and depressant roles in the brain. Supplementation can improve sleep quality.

Our evidence-based analysis on glycine features 151 unique references to scientific papers.

Research analysis led by .
Reviewed by
Examine.com Team
Last Updated:

How to Take

Medical Disclaimer

Recommended dosage, active amounts, other details

For glycemic and sleep benefits, doses of 3-5 grams with meals and before bed, respectively, have been used successfully in clinical research.


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Human Effect Matrix

Unlocked for Examine members

The Human Effect Matrix summarizes human studies to tell you what effects Glycine has on your body, how much evidence there is, and how strong these effects are.

Full details are available to Examine members.
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Minor Very High See 2 studies
There are improvements in cognition due to glycine being able to treat schizophrenia and due to glycine being able to improve sleep; two states of impaired cognition.
grade-c Minor Very High See 2 studies
The reduction in fatigue may solely be secondary to how Glycine supplementation can improve sleep quality
grade-c Minor Very High See all 3 studies
In persons undergoing mild sleep deprivation, 3g of glycine an hour prior to sleep is able to increase sleep quality and improve self-reports of fatigue and well being the next day due to better sleep.
grade-c Minor - See study
Is able to decrease symptoms of schizophrenia similar to both D-serine and sarcosine, but this occurs at an impractically high dose (minimum effective dose being around 800mg/kg bodyweight)

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Things to Note

Click here to see all 151 references.