Fat Loss

A compound that is designed or used to reduce fat mass through various means; does not inherently specify any interactions with muscle tissue, and many fat burners tend to be stimulatory.

This page contains all supplements touted to cause fat loss, although not all are successful.

This page features 126 unique references to scientific papers.

Research analysis by and verified by the Examine.com Research Team. Last updated on Jun 14, 2018.


If you are looking for a list of supplements to take to help with fat loss, we recommend you look at our fat loss supplements.

The goal of any fat-burning compound is to increase the rate of fat loss. This can be achieved by either increasing the overall metabolic rate, the amount of calories that come from fat relative to other sources, or to raise limits placed on fat cells in regards to releasing fatty acids. Some newer fat burning compounds can also work via uncoupling, which is the process of creating heat inside of a cell.

Other compounds that augment the above reactions can be classified as fat burners.

Fat burners typically act directly on the fat cell, as is the case with yohimbine, or vicariously through some hormones like adrenaline (as is the case with caffeine).

If you are looking for a list of supplements to take to help with fat loss, we recommend you look at our fat loss supplement stack

Things to Know

Also Known As

fat burning, fat burner, fat burners

Caution Notice

Although not applicable to all, many fat burners increase levels of adrenaline in the body and should be approached with caution for those suffering from cardiac ailments or high blood pressure.

Many fat-burners are also neurologically active, and caution should be taken when one also uses neurologically active compounds like anti-depressants, be they prescription medication or supplemental.

Examine.com Medical Disclaimer

Frequently Asked Questions

Questions and answers regarding Fat Loss

Q: How do I lose fat around my belly?

Read full answer to "How do I lose fat around my belly?"

Q: Will lifting weights convert my fat into muscle?

Read full answer to "Will lifting weights convert my fat into muscle?"

Q: Does diet soda inhibit fat loss?

A: It does not inhibit fat loss at all, and may actually suppress appetite that could help fat loss (although it does not induce fat loss per se either). Diet soda, in regards to body fat, is a carbonated inert beverage

Read full answer to "Does diet soda inhibit fat loss?"

Q: How do I stay out of "starvation mode?"

A: Marasmus is a disease of caloric restriction, but you most likely don't have it. Your metabolic rate can definitely slow down during weight loss, but it will never slow to the point where it causes you to gain weight; in this sense, starvation mode is a myth.

Read full answer to "How do I stay out of "starvation mode?""

Q: I have lost significant weight and now have loose skin. How can I tighten up my skin?

Read full answer to "I have lost significant weight and now have loose skin. How can I tighten up my skin?"

Q: Can hypothyroidism lead to fat gain?

A: Yes, a less active thyroid will reduce metabolic rate and can cause some weight gain. It is not a lot of weight gain though, and a subactive thyroid is not an excuse for obesity (if hypothyroidic, please see a doctor for medication; it burns fat)

Read full answer to "Can hypothyroidism lead to fat gain?"

Q: How do I get a six-pack?

A: You eat less food to reduce body fat. There will be abdominal muscles under the fat, and adding some muscle to this area (resistance training) can make them appear more aesthetic; fat loss is the main predictor, however

Read full answer to "How do I get a six-pack?"

Q: What should I eat for weight loss?

A: When it comes to weight loss, the most important factor is eating less. When you consume less calories than you spend you will lose weight and the diet that helps you lose weight best will be the one that allows you to consume less calories without causing much distress or lethargy.

Read full answer to "What should I eat for weight loss?"

Q: Will carbs make me fat?

A: They can if you eat more calories than you should be eating, which is definitely a concern as carbohydrates are disconnected from the sensation of fullness in some people (preceding overeating). Inherently though, carbs do not cause more fat gain than the caloric load suggests

Read full answer to "Will carbs make me fat?"

Q: How does protein affect weight loss?

Read full answer to "How does protein affect weight loss?"

Q: Does eating at night make it more likely to gain weight?

A: While the evidence is mixed, depending on who was studied and what the diets were, there does not seem to be a major inherent weight-gain effect when eating late at night. Individual results may vary, and other factors such as circadian rhythms should be considered as well.

Read full answer to "Does eating at night make it more likely to gain weight?"

Q: Does Garcinia Cambogia help with weight loss?

A: Garcinia Cambogia does not appear to help with weight loss in humans despite its popularity, and this is due to a profound difference in how it affects rats and humans.

Read full answer to "Does Garcinia Cambogia help with weight loss?"

Q: A compound from beer may help fat loss

A: A recent study shows that a compound in beer may help with fat loss.

Read full answer to "A compound from beer may help fat loss"

Q: How to minimize fat gain during the holidays

A: Holiday season is when most people gain weight (and then struggle to take it off). Overfeeding on protein could be your solution in helping minimize the fat gain.

Read full answer to "How to minimize fat gain during the holidays"

Q: Does high-protein intake help when dieting?

A: We analyze a study which suggests that a higher protein-intake while dieting can help you lose more fat.

Read full answer to "Does high-protein intake help when dieting?"

Q: Measuring body fat percentage: It's an accuracy thing

A: Comparing DEXA versus Bod Pod for people with different BMI.

Read full answer to "Measuring body fat percentage: It's an accuracy thing"

Q: How important is sleep?

A: Sleep is incredibly important, and can be considered crucial alongside diet and exercise. Proper sleep habits help sustain many biological processes, and bad sleep can cause these processes to be suboptimal or even malfunction.

Read full answer to "How important is sleep?"

Supplements that are primary Fat Loss

on Examine.com

Scientific Support & Reference Citations

Scientific support for each compound can be found vicariously through their respective pages.

Via HEM and FAQ:

  1. Vispute SS, et al. The effect of abdominal exercise on abdominal fat. J Strength Cond Res. (2011)
  2. Green JS, et al. The effects of exercise training on abdominal visceral fat, body composition, and indicators of the metabolic syndrome in postmenopausal women with and without estrogen replacement therapy: the HERITAGE family study. Metabolism. (2004)
  3. Du M, Yin J, Zhu MJ. Cellular signaling pathways regulating the initial stage of adipogenesis and marbling of skeletal muscle. Meat Sci. (2010)
  4. Frayn KN. Fat as a fuel: emerging understanding of the adipose tissue-skeletal muscle axis. Acta Physiol (Oxf). (2010)
  5. GOLDNER F Jr. A review of the transamination reaction and its relationship to acute myocardial infarction. Am Pract Dig Treat. (1957)
  6. Hirotsu K, et al. Dual substrate recognition of aminotransferases. Chem Rec. (2005)
  7. Phillips SM. The science of muscle hypertrophy: making dietary protein count. Proc Nutr Soc. (2011)
  8. Phillips SM, Hartman JW, Wilkinson SB. Dietary protein to support anabolism with resistance exercise in young men. J Am Coll Nutr. (2005)
  9. Maersk M, et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr. (2011)
  10. Tate DF, et al. Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial. Am J Clin Nutr. (2012)
  11. Wang YC, et al. Impact of change in sweetened caloric beverage consumption on energy intake among children and adolescents. Arch Pediatr Adolesc Med. (2009)
  12. Chen L, et al. Reduction in consumption of sugar-sweetened beverages is associated with weight loss: the PREMIER trial. Am J Clin Nutr. (2009)
  13. Davidson TL, Swithers SE. A Pavlovian approach to the problem of obesity. Int J Obes Relat Metab Disord. (2004)
  14. Minnesota Starvation Experiment.
  15. Schwartz A, Doucet E. Relative changes in resting energy expenditure during weight loss: a systematic review. Obes Rev. (2010)
  16. Features of a successful therapeutic fast of 382 days' duration.
  17. Grossman R. The role of dimethylaminoethanol in cosmetic dermatology. Am J Clin Dermatol. (2005)
  18. Uhoda I, et al. Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel. Skin Res Technol. (2002)
  19. Tadini KA, Campos PM. In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation. Pharmazie. (2009)
  20. Thyroid.org: Thyroid and Weight.
  21. Dale J, et al. Weight gain following treatment of hyperthyroidism. Clin Endocrinol (Oxf). (2001)
  22. Fox CS, et al. Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. Arch Intern Med. (2008)
  23. Karmisholt J, Andersen S, Laurberg P. Weight loss after therapy of hypothyroidism is mainly caused by excretion of excess body water associated with myxoedema. J Clin Endocrinol Metab. (2011)
  24. Crocker MK, Kaplowitz P. Treatment of paediatric hyperthyroidism but not hypothyroidism has a significant effect on weight. Clin Endocrinol (Oxf). (2010)
  25. Swinburn B, Sacks G, Ravussin E. Increased food energy supply is more than sufficient to explain the US epidemic of obesity. Am J Clin Nutr. (2009)
  26. Lack of evidence for high fructose corn syrup as the cause of the obesity epidemic.
  27. Leibel RL, et al. Energy intake required to maintain body weight is not affected by wide variation in diet composition. Am J Clin Nutr. (1992)
  28. Golay A, et al. Similar weight loss with low- or high-carbohydrate diets. Am J Clin Nutr. (1996)
  29. Golay A, et al. Weight-loss with low or high carbohydrate diet. Int J Obes Relat Metab Disord. (1996)
  30. Luscombe-Marsh ND, et al. Carbohydrate-restricted diets high in either monounsaturated fat or protein are equally effective at promoting fat loss and improving blood lipids. Am J Clin Nutr. (2005)
  31. Bray GA, et al. Effect of dietary protein content on weight gain, energy expenditure, and body composition during overeating: a randomized controlled trial. JAMA. (2012)
  32. Noakes M, et al. Effect of an energy-restricted, high-protein, low-fat diet relative to a conventional high-carbohydrate, low-fat diet on weight loss, body composition, nutritional status, and markers of cardiovascular health in obese women. Am J Clin Nutr. (2005)
  33. Keogh JB, et al. Long-term weight maintenance and cardiovascular risk factors are not different following weight loss on carbohydrate-restricted diets high in either monounsaturated fat or protein in obese hyperinsulinaemic men and women. Br J Nutr. (2007)
  34. Farnsworth E, et al. Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women. Am J Clin Nutr. (2003)
  35. Brinkworth GD, et al. Long-term effects of a high-protein, low-carbohydrate diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects. Int J Obes Relat Metab Disord. (2004)
  36. McLaughlin T, et al. Effects of moderate variations in macronutrient composition on weight loss and reduction in cardiovascular disease risk in obese, insulin-resistant adults. Am J Clin Nutr. (2006)
  37. Sargrad KR, et al. Effect of high protein vs high carbohydrate intake on insulin sensitivity, body weight, hemoglobin A1c, and blood pressure in patients with type 2 diabetes mellitus. J Am Diet Assoc. (2005)
  38. Boden G, et al. Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes. Ann Intern Med. (2005)
  39. Heilbronn LK, Noakes M, Clifton PM. Effect of energy restriction, weight loss, and diet composition on plasma lipids and glucose in patients with type 2 diabetes. Diabetes Care. (1999)
  40. Parker B, et al. Effect of a high-protein, high-monounsaturated fat weight loss diet on glycemic control and lipid levels in type 2 diabetes. Diabetes Care. (2002)
  41. Thomson RL, et al. The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. (2008)
  42. Strasser B, Spreitzer A, Haber P. Fat loss depends on energy deficit only, independently of the method for weight loss. Ann Nutr Metab. (2007)
  43. Astrup A, Meinert Larsen T, Harper A. Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss. Lancet. (2004)
  44. Golay A, et al. Similar weight loss with low-energy food combining or balanced diets. Int J Obes Relat Metab Disord. (2000)
  45. Hellerstein MK. De novo lipogenesis in humans: metabolic and regulatory aspects. Eur J Clin Nutr. (1999)
  46. Hellerstein MK. No common energy currency: de novo lipogenesis as the road less traveled. Am J Clin Nutr. (2001)
  47. McDevitt RM, et al. De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women. Am J Clin Nutr. (2001)
  48. Schwarz JM, et al. Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection. J Clin Invest. (1995)
  49. Sofer S, et al. Greater weight loss and hormonal changes after 6 months diet with carbohydrates eaten mostly at dinner. Obesity (Silver Spring). (2011)
  50. Evans EM, et al. Effects of protein intake and gender on body composition changes: a randomized clinical weight loss trial. Nutr Metab (Lond). (2012)
  51. Bopp MJ, et al. Lean mass loss is associated with low protein intake during dietary-induced weight loss in postmenopausal women. J Am Diet Assoc. (2008)
  52. Mojtahedi MC, et al. The effects of a higher protein intake during energy restriction on changes in body composition and physical function in older women. J Gerontol A Biol Sci Med Sci. (2011)
  53. Gordon MM, et al. Effects of dietary protein on the composition of weight loss in post-menopausal women. J Nutr Health Aging. (2008)
  54. Treyzon L, et al. A controlled trial of protein enrichment of meal replacements for weight reduction with retention of lean body mass. Nutr J. (2008)
  55. Clifton PM, Bastiaans K, Keogh JB. High protein diets decrease total and abdominal fat and improve CVD risk profile in overweight and obese men and women with elevated triacylglycerol. Nutr Metab Cardiovasc Dis. (2009)
  56. Josse AR, et al. Increased consumption of dairy foods and protein during diet- and exercise-induced weight loss promotes fat mass loss and lean mass gain in overweight and obese premenopausal women. J Nutr. (2011)
  57. Labayen I, et al. Effects of protein vs. carbohydrate-rich diets on fuel utilisation in obese women during weight loss. Forum Nutr. (2003)
  58. de Souza RJ, et al. Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial. Am J Clin Nutr. (2012)
  59. Loenneke JP, et al. Quality protein intake is inversely related with abdominal fat. Nutr Metab (Lond). (2012)
  60. Loenneke JP, et al. Short report: Relationship between quality protein, lean mass and bone health. Ann Nutr Metab. (2010)
  61. Nonino-Borges CB, et al. Influence of meal time on salivary circadian cortisol rhythms and weight loss in obese women. Nutrition. (2007)
  62. Jakubowicz D, et al. High caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women. Obesity (Silver Spring). (2013)
  63. James D. LeCheminant, et al. Restricting night-time eating reduces daily energy intake in healthy young men: a short-term cross-over study. British Journal of Nutrition. (2013)
  64. Keim NL, et al. Weight loss is greater with consumption of large morning meals and fat-free mass is preserved with large evening meals in women on a controlled weight reduction regimen. J Nutr. (1997)
  65. Goel N, et al. Circadian rhythm profiles in women with night eating syndrome. J Biol Rhythms. (2009)
  66. Patton DF, Mistlberger RE.. Circadian adaptations to meal timing: neuroendocrine mechanisms. Front Neurosci.. (2013)
  67. Watson JA, Lowenstein JM. Citrate and the conversion of carbohydrate into fat. Fatty acid synthesis by a combination of cytoplasm and mitochondria. J Biol Chem. (1970)
  68. Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. (1998)
  69. Kim JE, et al. Does Glycine max leaves or Garcinia Cambogia promote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial. Nutr J. (2011)
  70. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav. (2000)
  71. Leonhardt M, Hrupka B, Langhans W. Effect of hydroxycitrate on food intake and body weight regain after a period of restrictive feeding in male rats. Physiol Behav. (2001)
  72. Leonhardt M, Balkan B, Langhans W. Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding. Nutrition. (2004)
  73. Yi S, et al. Short sleep duration in association with CT-scanned abdominal fat areas: the Hitachi Health Study. Int J Obes (Lond). (2012)
  74. Park SE, et al. The association between sleep duration and general and abdominal obesity in Koreans: data from the Korean National Health and Nutrition Examination Survey, 2001 and 2005. Obesity (Silver Spring). (2009)
  75. Hairston KG, et al. Sleep duration and five-year abdominal fat accumulation in a minority cohort: the IRAS family study. Sleep. (2010)
  76. Watson NF, et al. Sleep duration and body mass index in twins: a gene-environment interaction. Sleep. (2012)
  77. Di Milia L, Vandelanotte C, Duncan MJ. The association between short sleep and obesity after controlling for demographic, lifestyle, work and health related factors. Sleep Med. (2013)
  78. Nedeltcheva AV, et al. Insufficient sleep undermines dietary efforts to reduce adiposity. Ann Intern Med. (2010)
  79. Benedict C, et al. Acute Sleep Deprivation Enhances the Brain's Response to Hedonic Food Stimuli: An fMRI Study. J Clin Endocrinol Metab. (2012)
  80. St-Onge MP, et al. Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. Am J Clin Nutr. (2012)
  81. Bosy-Westphal A, et al. Influence of partial sleep deprivation on energy balance and insulin sensitivity in healthy women. Obes Facts. (2008)
  82. Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on physiological rhythms. Rev Neurol (Paris). (2003)
  83. Lemola S, et al. Optimism and Self-Esteem Are Related to Sleep. Results from a Large Community-Based Sample. Int J Behav Med. (2012)
  84. Sio UN, Monaghan P, Ormerod T. Sleep on it, but only if it is difficult: Effects of sleep on problem solving. Mem Cognit. (2012)
  85. Knutson KL. Sleep duration and cardiometabolic risk: a review of the epidemiologic evidence. Best Pract Res Clin Endocrinol Metab. (2010)
  86. Choi JK, et al. Association between short sleep duration and high incidence of metabolic syndrome in midlife women. Tohoku J Exp Med. (2011)
  87. Najafian J, et al. Association between sleep duration and metabolic syndrome in a population-based study: Isfahan Healthy Heart Program. J Res Med Sci. (2011)
  88. Cappuccio FP, et al. Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care. (2010)
  89. Beihl DA, Liese AD, Haffner SM. Sleep duration as a risk factor for incident type 2 diabetes in a multiethnic cohort. Ann Epidemiol. (2009)
  90. Chaput JP, et al. Sleep duration as a risk factor for the development of type 2 diabetes or impaired glucose tolerance: analyses of the Quebec Family Study. Sleep Med. (2009)
  91. Chao CY, et al. Sleep duration is a potential risk factor for newly diagnosed type 2 diabetes mellitus. Metabolism. (2011)
  92. Broussard JL, et al. Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study. Ann Intern Med. (2012)
  93. Robertson MD, et al. Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men. Metabolism. (2013)
  94. Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men.
  95. Buxton OM, et al. Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes. (2010)
  96. Donga E, et al. A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. J Clin Endocrinol Metab. (2010)
  97. Penev PD. Association between sleep and morning testosterone levels in older men. Sleep. (2007)
  98. Luboshitzky R, Shen-Orr Z, Herer P. Middle-aged men secrete less testosterone at night than young healthy men. J Clin Endocrinol Metab. (2003)
  99. Randler C, et al. Chronotype but not sleep length is related to salivary testosterone in young adult men. Psychoneuroendocrinology. (2012)
  100. Validation of the full and reduced Composite Scale of Morningness.
  101. An actigraphic validation study of seven morningness-eveningness inventories.
  102. Roenneberg T, et al. A marker for the end of adolescence. Curr Biol. (2004)
  103. Leproult R, Van Cauter E. Effect of 1 week of sleep restriction on testosterone levels in young healthy men. JAMA. (2011)
  104. Cortés-Gallegos V, et al. Sleep deprivation reduces circulating androgens in healthy men. Arch Androl. (1983)
  105. González-Santos MR, et al. Sleep deprivation and adaptive hormonal responses of healthy men. Arch Androl. (1989)
  106. Cote KA, et al. Sleep deprivation lowers reactive aggression and testosterone in men. Biol Psychol. (2013)
  107. Leproult R, et al. Sleep loss results in an elevation of cortisol levels the next evening. Sleep. (1997)
  108. Backhaus J, Junghanns K, Hohagen F. Sleep disturbances are correlated with decreased morning awakening salivary cortisol. Psychoneuroendocrinology. (2004)
  109. Wu H, et al. Effects of sleep restriction periods on serum cortisol levels in healthy men. Brain Res Bull. (2008)
  110. Vgontzas AN, et al. Sleep deprivation effects on the activity of the hypothalamic-pituitary-adrenal and growth axes: potential clinical implications. Clin Endocrinol (Oxf). (1999)
  111. Caine-Bish N, et al. The effect of cold exposure on the hormonal and metabolic responses to sleep deprivation. Wilderness Environ Med. (2005)
  112. Opstad PK, et al. The thyroid function in young men during prolonged exercise and the effect of energy and sleep deprivation. Clin Endocrinol (Oxf). (1984)
  113. Sadamatsu M, et al. The 24-hour rhythms in plasma growth hormone, prolactin and thyroid stimulating hormone: effect of sleep deprivation. J Neuroendocrinol. (1995)
  114. Klingenberg L, et al. Sleep restriction is not associated with a positive energy balance in adolescent boys. Am J Clin Nutr. (2012)
  115. Koban M, Swinson KL. Chronic REM-sleep deprivation of rats elevates metabolic rate and increases UCP1 gene expression in brown adipose tissue. Am J Physiol Endocrinol Metab. (2005)
  116. Rechtschaffen A, Bergmann BM. Sleep deprivation in the rat: an update of the 1989 paper. Sleep. (2002)
  117. Takahashi Y, Kipnis DM, Daughaday WH. Growth hormone secretion during sleep. J Clin Invest. (1968)
  118. Sassin JF, et al. Human growth hormone release: relation to slow-wave sleep and sleep-walking cycles. Science. (1969)
  119. Gronfier C, et al. A quantitative evaluation of the relationships between growth hormone secretion and delta wave electroencephalographic activity during normal sleep and after enrichment in delta waves. Sleep. (1996)
  120. Van Cauter E, et al. A quantitative estimation of growth hormone secretion in normal man: reproducibility and relation to sleep and time of day. J Clin Endocrinol Metab. (1992)
  121. Obál F Jr, Krueger JM. The somatotropic axis and sleep. Rev Neurol (Paris). (2001)
  122. Saini J, et al. Continuous positive airway pressure treatment. Effects on growth hormone, insulin and glucose profiles in obstructive sleep apnea patients. Horm Metab Res. (1993)
  123. Brandenberger G, Weibel L. The 24-h growth hormone rhythm in men: sleep and circadian influences questioned. J Sleep Res. (2004)
  124. Ho KY, et al. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab. (1987)
  125. Brandenberger G, et al. Effect of sleep deprivation on overall 24 h growth-hormone secretion. Lancet. (2000)
  126. Spiegel K, et al. Adaptation of the 24-h growth hormone profile to a state of sleep debt. Am J Physiol Regul Integr Comp Physiol. (2000)