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Chaga, also known as Inonotus obliquus, is a mushroom commonly used as a dietary supplement. There are claims that it has beneficial effects on immune function and cancer prevention. However, these claims are limited to in vitro (studies done in petri dishes or test tubes) and animal studies, as there is only one study in humans.[1]

Our evidence-based analysis on chaga features 24 unique references to scientific papers.

Research analysis led by and reviewed by the Examine team.
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  1. ^ a b E A Dosychev, V N Bystrova. Treatment o psoriasis using "Chaga" fungus preparations. Vestn Dermatol Venerol. (1973)
  2. ^ Konrad A Szychowski, et al. Inonotus obliquus - from folk medicine to clinical use. J Tradit Complement Med. (2020)
  3. ^ Yangpeng Lu, et al. Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application. Polymers (Basel). (2021)
  4. ^ Myung-Ja Youn, et al. Potential anticancer properties of the water extract of Inonotus corrected obliquus by induction of apoptosis in melanoma B16-F10 cells. J Ethnopharmacol. (2009)
  5. ^ Dong Pil Won, et al. Immunostimulating activity by polysaccharides isolated from fruiting body of Inonotus obliquus. Mol Cells. (2011)
  6. ^ Jin Tian, et al. Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses. Int J Biol Macromol. (2017)
  7. ^ Hong-Hui Pan, et al. Aqueous extract from a Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion. Int J Med Mushrooms. (2013)
  8. ^ V A Shibnev, et al. Antiviral activity of Inonotus obliquus fungus extract towards infection caused by hepatitis C virus in cell cultures. Bull Exp Biol Med. (2011)
  9. ^ Haibo Mu, et al. Antioxidative properties of crude polysaccharides from Inonotus obliquus. Int J Mol Sci. (2012)
  10. ^ Xiangqun Xu, Yan Hu, Lili Quan. Production of bioactive polysaccharides by Inonotus obliquus under submerged fermentation supplemented with lignocellulosic biomass and their antioxidant activity. Bioprocess Biosyst Eng. (2014)
  11. ^ Ye Chan Sim, et al. Effects of polysaccharides isolated from Inonotus obliquus against hydrogen peroxide-induced oxidative damage in RINm5F pancreatic β-cells. Mol Med Rep. (2016)
  12. ^ Trishna Debnath, et al. Anti-oxidant and anti-inflammatory activities of Inonotus obliquus and germinated brown rice extracts. Molecules. (2013)
  13. ^ Chun-Jing Zhang, et al. Spatial structure and anti-fatigue of polysaccharide from Inonotus obliquus. Int J Biol Macromol. (2020)
  14. ^ Zhong Yue, et al. Effect of Inonotus Obliquus Polysaccharides on physical fatigue in mice. J Tradit Chin Med. (2015)
  15. ^ Yang Hu, et al. Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice. AMB Express. (2017)
  16. ^ a b c Jasmina Glamočlija, et al. Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal "mushroom". J Ethnopharmacol. (2015)
  17. ^ a b c Sua Lee, et al. Development of End Stage Renal Disease after Long-Term Ingestion of Chaga Mushroom: Case Report and Review of Literature. J Korean Med Sci. (2020)
  18. ^ a b Yuko Kikuchi, et al. Chaga mushroom-induced oxalate nephropathy. Clin Nephrol. (2014)
  19. ^ D O'Shea, D Powell. Growth hormone therapy in Turner's syndrome. Ir Med J. (1992)
  20. ^ You-Min Ying, et al. Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus. Phytochemistry. (2014)
  21. ^ John Knight, et al. Ascorbic acid intake and oxalate synthesis. Urolithiasis. (2016)
  22. ^ S Mashour, J F Turner Jr, R Merrell. Acute renal failure, oxalosis, and vitamin C supplementation: a case report and review of the literature. Chest. (2000)
  23. ^ Jorge Lamarche, et al. Vitamin C-induced oxalate nephropathy. Int J Nephrol. (2011)
  24. ^ Weijie Violet Lin, et al. Ascorbic acid-induced oxalate nephropathy: a case report and discussion of pathologic mechanisms. CEN Case Rep. (2019)