Cardiovascular Health

Last Updated: February 11, 2023

Cardiovascular health has to do with how well the heart and blood vessels carry blood throughout the body. Preventing disease is a major aspect of cardiovascular health, though performance and optimization are also frequently studied.

What does cardiovascular health encompass?

Cardiovascular health describes how well, or how poorly, the heart (“cardio-”) and blood vessels (“-vascular”) move blood throughout the body. Conditions like coronary artery disease and atherosclerosis are commonly associated with cardiovascular health. However, not all cardiovascular diseases have to do with clogged and hardened blood vessels. For example, Raynaud's disease, varicose veins,[1] and congenital heart diseases[2] are also categorized under cardiovascular health. Metrics like heart rate variability and resting heart rate are also linked to cardiovascular health to some degree, but their significance is still being explored.[3][4]

How could diet affect cardiovascular health?

Diet can have major potential effects on cardiovascular health, although the specifics depend on the aspect of health in question. For example, there’s strong evidence to suggest that a diet low in salt and high in fruits, vegetables, whole grains, and fish[5] like the Mediterranean diet[6] is effective for the prevention of atherosclerotic cardiovascular disease, and diets high in nitrate-containing foods like beetroot juice, kale, and spinach may have the potential to improve cardiovascular aspects of athletic performance, although the magnitude of these effects for high-performing athletes is questionable.[7]

Which supplements are of most interest for cardiovascular health?

Fish oil has been particularly well studied in the context of cardiovascular health. Several vitamins like folic acid, vitamin D, and vitamin E have also been investigated, as have plant-based supplements like pycnogenol and high-nitrate beetroot juice. Red yeast rice can lower cholesterol, although any supplement with high levels of its active ingredient (lovastatin) cannot be sold legally in the United States. In contrast, some evidence suggests that calcium supplementation may negatively affect cardiovascular health.[8]

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References
  1. ^Medline Plus: Vascular Diseases. Accessed 5/30/22
  2. ^Medline Plus: Heart Diseases. Accessed 5/30/22
  3. ^Larsson SC, Drca N, Mason AM, Burgess SResting Heart Rate and Cardiovascular Disease.Circ Genom Precis Med.(2019-03)
  4. ^Souza HCD, Philbois SV, Veiga AC, Aguilar BAHeart Rate Variability and Cardiovascular Fitness: What We Know so Far.Vasc Health Risk Manag.(2021)
  5. ^Donna K Arnett, Roger S Blumenthal, Michelle A Albert, Andrew B Buroker, Zachary D Goldberger, Ellen J Hahn, Cheryl Dennison Himmelfarb, Amit Khera, Donald Lloyd-Jones, J William McEvoy, Erin D Michos, Michael D Miedema, Daniel Muñoz, Sidney C Smith Jr, Salim S Virani, Kim A Williams Sr, Joseph Yeboah, Boback Ziaeian2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice GuidelinesCirculation.(2019 Sep 10)
  6. ^Frank L J Visseren, François Mach, Yvo M Smulders, David Carballo, Konstantinos C Koskinas, Maria Bäck, Athanase Benetos, Alessandro Biffi, José-Manuel Boavida, Davide Capodanno, Bernard Cosyns, Carolyn Crawford, Constantinos H Davos, Ileana Desormais, Emanuele Di Angelantonio, Oscar H Franco, Sigrun Halvorsen, F D Richard Hobbs, Monika Hollander, Ewa A Jankowska, Matthias Michal, Simona Sacco, Naveed Sattar, Lale Tokgozoglu, Serena Tonstad, Konstantinos P Tsioufis, Ineke van Dis, Isabelle C van Gelder, Christoph Wanner, Bryan Williams, ESC Scientific Document Group, ESC National Cardiac Societies2021 ESC Guidelines on cardiovascular disease prevention in clinical practiceEur Heart J.(2021 Sep 7)
  7. ^Woessner MN, McIlvenna LC, Ortiz de Zevallos J, Neil CJ, Allen JDDietary nitrate supplementation in cardiovascular health: an ergogenic aid or exercise therapeutic?Am J Physiol Heart Circ Physiol.(2018-02-01)
  8. ^Seung-Kwon Myung, Hong-Bae Kim, Yong-Jae Lee, Yoon-Jung Choi, Seung-Won OhCalcium Supplements and Risk of Cardiovascular Disease: A Meta-Analysis of Clinical TrialsNutrients.(2021 Jan 26)
  9. ^Wikoff D, Welsh BT, Henderson R, Brorby GP, Britt J, Myers E, Goldberger J, Lieberman HR, O'Brien C, Peck J, Tenenbein M, Weaver C, Harvey S, Urban J, Doepker CSystematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and childrenFood Chem Toxicol.(2017 Nov)
  10. ^Poole R, Kennedy OJ, Roderick P, Fallowfield JA, Hayes PC, Parkes JCoffee consumption and health: umbrella review of meta-analyses of multiple health outcomesBMJ.(2017 Nov 22)
  11. ^Voskoboinik A, Kalman JM, Kistler PMCaffeine and Arrhythmias: Time to Grind the DataJACC Clin Electrophysiol.(2018 Apr)
  12. ^Hansen D, Niebauer J, Cornelissen V, Barna O, Neunhäuserer D, Stettler C, Tonoli C, Greco E, Fagard R, Coninx K, Vanhees L, Piepoli MF, Pedretti R, Ruiz GR, Corrà U, Schmid JP, Davos CH, Edelmann F, Abreu A, Rauch B, Ambrosetti M, Braga SS, Beckers P, Bussotti M, Faggiano P, Garcia-Porrero E, Kouidi E, Lamotte M, Reibis R, Spruit MA, Takken T, Vigorito C, Völler H, Doherty P, Dendale PExercise Prescription in Patients with Different Combinations of Cardiovascular Disease Risk Factors: A Consensus Statement from the EXPERT Working GroupSports Med.(2018 Aug)
  13. ^Poudyal H, Brown LShould the pharmacological actions of dietary fatty acids in cardiometabolic disorders be classified based on biological or chemical function?Prog Lipid Res.(2015 Jul)
  14. ^Grundy SMInfluence of stearic acid on cholesterol metabolism relative to other long-chain fatty acidsAm J Clin Nutr.(1994 Dec)
  15. ^Vandenberghe C, St-Pierre V, Pierotti T, Fortier M, Castellano C, Cunnane STricaprylin alone increases plasma ketone response more than coconut oil or other medium chain triglycerides: an acute crossover study in healthy adultsCurr Dev Nutr.(2017 Mar)
  16. ^Neal EG, Chaffe H, Schwartz RH, Lawson MS, Edwards N, Fitzsimmons G, Whitney A, Cross JHA randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsyEpilepsia.(2009 May)
  17. ^Orsavova J, Misurcova L, Ambrozova JV, Vicha R, Mlcek JFatty Acids Composition of Vegetable Oils and Its Contribution to Dietary Energy Intake and Dependence of Cardiovascular Mortality on Dietary Intake of Fatty AcidsInt J Mol Sci.(2015 Jun 5)
  18. ^KEYS A, ANDERSON JT, GRANDE FPrediction of serum-cholesterol responses of man to changes in fats in the dietLancet.(1957 Nov 16)
  19. ^KEYS A, GRANDE FRole of dietary fat in human nutrition. III. Diet and the epidemiology of coronary heart diseaseAm J Public Health Nations Health.(1957 Dec)
  20. ^Keys A, Menotti A, Aravanis C, Blackburn H, Djordevic BS, Buzina R, Dontas AS, Fidanza F, Karvonen MJ, Kimura NThe seven countries study: 2,289 deaths in 15 yearsPrev Med.(1984 Mar)
  21. ^Keys A, Menotti A, Karvonen MJ, Aravanis C, Blackburn H, Buzina R, Djordjevic BS, Dontas AS, Fidanza F, Keys MHThe diet and 15-year death rate in the seven countries studyAm J Epidemiol.(1986 Dec)
  22. ^Reiser RSaturated fat in the diet and serum cholesterol concentration: a critical examination of the literatureAm J Clin Nutr.(1973 May)
  23. ^Tabas I, Williams KJ, Borén JSubendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implicationsCirculation.(2007 Oct 16)
  24. ^Lusis AJAtherosclerosisNature.(2000 Sep 14)
  25. ^World Health OrganizationEffects of saturated fatty acids on serum lipids and lipoproteins: a systematic review and regression analysis(2016)
  26. ^Allaire J, Vors C, Couture P, Lamarche BLDL particle number and size and cardiovascular risk: anything new under the sun?Curr Opin Lipidol.(2017 Jun)
  27. ^Otvos JD, Mora S, Shalaurova I, Greenland P, Mackey RH, Goff DC JrClinical implications of discordance between low-density lipoprotein cholesterol and particle numberJ Clin Lipidol.(2011 Mar-Apr)
  28. ^Contois JH, McConnell JP, Sethi AA, Csako G, Devaraj S, Hoefner DM, Warnick GR, AACC Lipoproteins and Vascular Diseases Division Working Group on Best PracticesApolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best PracticesClin Chem.(2009 Mar)
  29. ^Sniderman AD, Williams K, Contois JH, Monroe HM, McQueen MJ, de Graaf J, Furberg CDA meta-analysis of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B as markers of cardiovascular riskCirc Cardiovasc Qual Outcomes.(2011 May)
  30. ^Feig JE, Feig JL, Dangas GDThe role of HDL in plaque stabilization and regression: basic mechanisms and clinical implicationsCoron Artery Dis.(2016 Nov)
  31. ^Millán J, Pintó X, Muñoz A, Zúñiga M, Rubiés-Prat J, Pallardo LF, Masana L, Mangas A, Hernández-Mijares A, González-Santos P, Ascaso JF, Pedro-Botet JLipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular preventionVasc Health Risk Manag.(2009)
  32. ^McQueen MJ, Hawken S, Wang X, Ounpuu S, Sniderman A, Probstfield J, Steyn K, Sanderson JE, Hasani M, Volkova E, Kazmi K, Yusuf S, INTERHEART study investigatorsLipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control studyLancet.(2008 Jul 19)
  33. ^Walldius G, Jungner I, Aastveit AH, Holme I, Furberg CD, Sniderman ADThe apoB/apoA-I ratio is better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic lipoproteins and to predict coronary riskClin Chem Lab Med.(2004)
  34. ^da Luz PL, Cesena FH, Favarato D, Cerqueira ESComparison of serum lipid values in patients with coronary artery disease at 70 years of ageAm J Cardiol.(2005 Dec 15)
  35. ^da Luz PL, Favarato D, Faria-Neto JR Jr, Lemos P, Chagas ACHigh ratio of triglycerides to HDL-cholesterol predicts extensive coronary diseaseClinics (Sao Paulo).(2008 Aug)
  36. ^Hanak V, Munoz J, Teague J, Stanley A Jr, Bittner VAccuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype BAm J Cardiol.(2004 Jul 15)
  37. ^Golia E, Limongelli G, Natale F, Fimiani F, Maddaloni V, Pariggiano I, Bianchi R, Crisci M, D'Acierno L, Giordano R, Di Palma G, Conte M, Golino P, Russo MG, Calabrò R, Calabrò PInflammation and cardiovascular disease: from pathogenesis to therapeutic targetCurr Atheroscler Rep.(2014 Sep)
  38. ^Bertrand MJ, Tardif JCInflammation and beyond: new directions and emerging drugs for treating atherosclerosisExpert Opin Emerg Drugs.(2017 Mar)
  39. ^Fritsche KLThe science of fatty acids and inflammationAdv Nutr.(2015 May 15)
  40. ^Rietschel ET, Kirikae T, Schade FU, Mamat U, Schmidt G, Loppnow H, Ulmer AJ, Zähringer U, Seydel U, Di Padova FBacterial endotoxin: molecular relationships of structure to activity and functionFASEB J.(1994 Feb)
  41. ^Miller SI, Ernst RK, Bader MWLPS, TLR4 and infectious disease diversityNat Rev Microbiol.(2005 Jan)
  42. ^Copeland S, Warren HS, Lowry SF, Calvano SE, Remick D, Inflammation and the Host Response to Injury InvestigatorsAcute inflammatory response to endotoxin in mice and humansClin Diagn Lab Immunol.(2005 Jan)
  43. ^Santos S, Oliveira A, Lopes CSystematic review of saturated fatty acids on inflammation and circulating levels of adipokinesNutr Res.(2013 Sep)
  44. ^Kratz M, Cullen P, Kannenberg F, Kassner A, Fobker M, Abuja PM, Assmann G, Wahrburg UEffects of dietary fatty acids on the composition and oxidizability of low-density lipoproteinEur J Clin Nutr.(2002 Jan)
  45. ^Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, Franco OH, Butterworth AS, Forouhi NG, Thompson SG, Khaw KT, Mozaffarian D, Danesh J, Di Angelantonio EAssociation of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysisAnn Intern Med.(2014 Mar 18)
  46. ^Siri-Tarino PW, Sun Q, Hu FB, Krauss RMMeta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular diseaseAm J Clin Nutr.(2010 Mar)
  47. ^Mozaffarian D, Micha R, Wallace SEffects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trialsPLoS Med.(2010 Mar 23)
  48. ^Ramsden CE, Hibbeln JR, Majchrzak SF, Davis JMn-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trialsBr J Nutr.(2010 Dec)
  49. ^Hamley SThe effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trialsNutr J.(2017 May 19)
  50. ^Månsson HLFatty acids in bovine milk fatFood Nutr Res.(2008)
  51. ^Huth PJ, Park KMInfluence of dairy product and milk fat consumption on cardiovascular disease risk: a review of the evidenceAdv Nutr.(2012 May 1)
  52. ^Lovegrove JA, Hobbs DANew perspectives on dairy and cardiovascular healthProc Nutr Soc.(2016 Aug)
  53. ^Rosqvist F, Smedman A, Lindmark-Månsson H, Paulsson M, Petrus P, Straniero S, Rudling M, Dahlman I, Risérus UPotential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized studyAm J Clin Nutr.(2015 Jul)
  54. ^O'Sullivan TA, Hafekost K, Mitrou F, Lawrence DFood sources of saturated fat and the association with mortality: a meta-analysisAm J Public Health.(2013 Sep)
  55. ^Vlassara H, Cai W, Tripp E, Pyzik R, Yee K, Goldberg L, Tansman L, Chen X, Mani V, Fayad ZA, Nadkarni GN, Striker GE, He JC, Uribarri JOral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trialDiabetologia.(2016 Oct)
  56. ^Briggs MA, Petersen KS, Kris-Etherton PMSaturated Fatty Acids and Cardiovascular Disease: Replacements for Saturated Fat to Reduce Cardiovascular RiskHealthcare (Basel).(2017 Jun 21)
  57. ^Zong G, Li Y, Sampson L, Dougherty LW, Willett WC, Wanders AJ, Alssema M, Zock PL, Hu FB, Sun QMonounsaturated fats from plant and animal sources in relation to risk of coronary heart disease among US men and womenThe American Journal of Clinical Nutrition.(2018)
  58. ^Hussain G, Schmitt F, Loeffler JP, Gonzalez de Aguilar JLFatting the brain: a brief of recent researchFront Cell Neurosci.(2013 Sep 9)
  59. ^Fernandes MF, Mutch DM, Leri FThe Relationship between Fatty Acids and Different Depression-Related Brain Regions, and Their Potential Role as Biomarkers of Response to AntidepressantsNutrients.(2017 Mar 17)
  60. ^Kien CL, Bunn JY, Tompkins CL, Dumas JA, Crain KI, Ebenstein DB, Koves TR, Muoio DMSubstituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in moodAm J Clin Nutr.(2013 Apr)
  61. ^Dumas JA, Bunn JY, Nickerson J, Crain KI, Ebenstein DB, Tarleton EK, Makarewicz J, Poynter ME, Kien CLDietary saturated fat and monounsaturated fat have reversible effects on brain function and the secretion of pro-inflammatory cytokines in young womenMetabolism.(2016 Oct)
  62. ^Sartorius T, Ketterer C, Kullmann S, Balzer M, Rotermund C, Binder S, Hallschmid M, Machann J, Schick F, Somoza V, Preissl H, Fritsche A, Häring HU, Hennige AMMonounsaturated fatty acids prevent the aversive effects of obesity on locomotion, brain activity, and sleep behaviorDiabetes.(2012 Jul)
  63. ^Kaviani S, Cooper JAAppetite responses to high-fat meals or diets of varying fatty acid composition: a comprehensive reviewEur J Clin Nutr.(2017 Oct)
  64. ^Krishnan S, Cooper JAEffect of dietary fatty acid composition on substrate utilization and body weight maintenance in humansEur J Nutr.(2014 Apr)
  65. ^Jones PJ, Pencharz PB, Clandinin MTWhole body oxidation of dietary fatty acids: implications for energy utilizationAm J Clin Nutr.(1985 Nov)
  66. ^Schmidt DE, Allred JB, Kien CLFractional oxidation of chylomicron-derived oleate is greater than that of palmitate in healthy adults fed frequent small mealsJ Lipid Res.(1999 Dec)
  67. ^Dorgan JF, Judd JT, Longcope C, Brown C, Schatzkin A, Clevidence BA, Campbell WS, Nair PP, Franz C, Kahle L, Taylor PREffects of dietary fat and fiber on plasma and urine androgens and estrogens in men: a controlled feeding studyAm J Clin Nutr.(1996 Dec)
  68. ^Wang C, Catlin DH, Starcevic B, Heber D, Ambler C, Berman N, Lucas G, Leung A, Schramm K, Lee PW, Hull L, Swerdloff RSLow-fat high-fiber diet decreased serum and urine androgens in menJ Clin Endocrinol Metab.(2005 Jun)
  69. ^Hämäläinen E, Adlercreutz H, Puska P, Pietinen PDiet and serum sex hormones in healthy menJ Steroid Biochem.(1984 Jan)
  70. ^Raben A, Kiens B, Richter EA, Rasmussen LB, Svenstrup B, Micic S, Bennett PSerum sex hormones and endurance performance after a lacto-ovo vegetarian and a mixed dietMed Sci Sports Exerc.(1992 Nov)
  71. ^Dam HThe antihaemorrhagic vitamin of the chickBiochem J.(1935 Jun)
  72. ^Booth SLRoles for vitamin K beyond coagulationAnnu Rev Nutr.(2009)
  73. ^Shearer MJ, Newman PRecent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesisJ Lipid Res.(2014 Mar)
  74. ^Garber AK, Binkley NC, Krueger DC, Suttie JWComparison of phylloquinone bioavailability from food sources or a supplement in human subjectsJ Nutr.(1999 Jun)
  75. ^Gijsbers BL, Jie KS, Vermeer CEffect of food composition on vitamin K absorption in human volunteersBr J Nutr.(1996 Aug)
  76. ^Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti GOral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice GuidelinesChest.(2012 Feb)
  77. ^Booth SLVitamin K: food composition and dietary intakesFood Nutr Res.(2012)
  78. ^Kurosu M, Begari EVitamin K2 in electron transport system: are enzymes involved in vitamin K2 biosynthesis promising drug targets?Molecules.(2010 Mar 10)
  79. ^Shearer MJ, Newman PMetabolism and cell biology of vitamin KThromb Haemost.(2008 Oct)
  80. ^Davidson RT, Foley AL, Engelke JA, Suttie JWConversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteriaJ Nutr.(1998 Feb)
  81. ^Ronden JE, Drittij-Reijnders MJ, Vermeer C, Thijssen HHIntestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the ratBiochim Biophys Acta.(1998 Jan 8)
  82. ^Beulens JW, Booth SL, van den Heuvel EG, Stoecklin E, Baka A, Vermeer CThe role of menaquinones (vitamin K₂) in human healthBr J Nutr.(2013 Oct)
  83. ^Miggiano GA, Robilotta LVitamin K-controlled diet: problems and prospectsClin Ter.(2005 Jan-Apr)
  84. ^Ichihashi T, Takagishi Y, Uchida K, Yamada HColonic absorption of menaquinone-4 and menaquinone-9 in ratsJ Nutr.(1992 Mar)
  85. ^Holmes MV, Hunt BJ, Shearer MJThe role of dietary vitamin K in the management of oral vitamin K antagonistsBlood Rev.(2012 Jan)
  86. ^Ikeda Y, Iki M, Morita A, Kajita E, Kagamimori S, Kagawa Y, Yoneshima HIntake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) StudyJ Nutr.(2006 May)
  87. ^Katsuyama H, Ideguchi S, Fukunaga M, Saijoh K, Sunami SUsual dietary intake of fermented soybeans (Natto) is associated with bone mineral density in premenopausal womenJ Nutr Sci Vitaminol (Tokyo).(2002 Jun)
  88. ^Sato T, Schurgers LJ, Uenishi KComparison of menaquinone-4 and menaquinone-7 bioavailability in healthy womenNutr J.(2012 Nov 12)
  89. ^Vermeer CVitamin K: the effect on health beyond coagulation - an overviewFood Nutr Res.(2012)
  90. ^Schurgers LJ, Teunissen KJ, Hamulyák K, Knapen MH, Vik H, Vermeer CVitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7Blood.(2007 Apr 15)
  91. ^Schurgers LJ, Vermeer CDifferential lipoprotein transport pathways of K-vitamins in healthy subjectsBiochim Biophys Acta.(2002 Feb 15)
  92. ^Schurgers LJ, Vermeer CDetermination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrationsHaemostasis.(2000 Nov-Dec)
  93. ^Nakagawa K, Hirota Y, Sawada N, Yuge N, Watanabe M, Uchino Y, Okuda N, Shimomura Y, Suhara Y, Okano TIdentification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzymeNature.(2010 Nov 4)
  94. ^Shearer MJVitamin KLancet.(1995 Jan 28)
  95. ^American Academy of Pediatrics Committee on Fetus and NewbornControversies concerning vitamin K and the newborn. American Academy of Pediatrics Committee on Fetus and NewbornPediatrics.(2003 Jul)
  96. ^Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer CTissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated ratsJ Vasc Res.(2003 Nov-Dec)
  97. ^Groenen-van Dooren MM, Soute BA, Jie KS, Thijssen HH, Vermeer CThe relative effects of phylloquinone and menaquinone-4 on the blood coagulation factor synthesis in vitamin K-deficient ratsBiochem Pharmacol.(1993 Aug 3)
  98. ^Theuwissen E, Teunissen KJ, Spronk HM, Hamulyák K, Ten Cate H, Shearer MJ, Vermeer C, Schurgers LJEffect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteersJ Thromb Haemost.(2013 Jun)
  99. ^Schurgers LJ, Shearer MJ, Hamulyák K, Stöcklin E, Vermeer CEffect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjectsBlood.(2004 Nov 1)
  100. ^Ushiroyama T, Ikeda A, Ueki MEffect of continuous combined therapy with vitamin K(2) and vitamin D(3) on bone mineral density and coagulofibrinolysis function in postmenopausal womenMaturitas.(2002 Mar 25)
  101. ^Asakura H, Myou S, Ontachi Y, Mizutani T, Kato M, Saito M, Morishita E, Yamazaki M, Nakao SVitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiencyOsteoporos Int.(2001 Dec)
  102. ^Mayer O Jr, Seidlerová J, Bruthans J, Filipovský J, Timoracká K, Vaněk J, Cerná L, Wohlfahrt P, Cífková R, Theuwissen E, Vermeer CDesphospho-uncarboxylated matrix Gla-protein is associated with mortality risk in patients with chronic stable vascular diseaseAtherosclerosis.(2014 Jul)
  103. ^Chatrou ML, Winckers K, Hackeng TM, Reutelingsperger CP, Schurgers LJVascular calcification: the price to pay for anticoagulation therapy with vitamin K-antagonistsBlood Rev.(2012 Jul)
  104. ^Gast GC, de Roos NM, Sluijs I, Bots ML, Beulens JW, Geleijnse JM, Witteman JC, Grobbee DE, Peeters PH, van der Schouw YTA high menaquinone intake reduces the incidence of coronary heart diseaseNutr Metab Cardiovasc Dis.(2009 Sep)
  105. ^Beulens JW, Bots ML, Atsma F, Bartelink ML, Prokop M, Geleijnse JM, Witteman JC, Grobbee DE, van der Schouw YTHigh dietary menaquinone intake is associated with reduced coronary calcificationAtherosclerosis.(2009 Apr)
  106. ^Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JCDietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam StudyJ Nutr.(2004 Nov)
  107. ^El Asmar MS, Naoum JJ, Arbid EJVitamin k dependent proteins and the role of vitamin k2 in the modulation of vascular calcification: a reviewOman Med J.(2014 May)
  108. ^Shea MK, O'Donnell CJ, Hoffmann U, Dallal GE, Dawson-Hughes B, Ordovas JM, Price PA, Williamson MK, Booth SLVitamin K supplementation and progression of coronary artery calcium in older men and womenAm J Clin Nutr.(2009 Jun)
  109. ^Braam LA, Hoeks AP, Brouns F, Hamulyák K, Gerichhausen MJ, Vermeer CBeneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up studyThromb Haemost.(2004 Feb)
  110. ^Kurnatowska I, Grzelak P, Masajtis-Zagajewska A, Kaczmarska M, Stefańczyk L, Vermeer C, Maresz K, Nowicki MEffect of vitamin K2 on progression of atherosclerosis and vascular calcification in nondialyzed patients with chronic kidney disease stages 3-5Pol Arch Med Wewn.(2015)
  111. ^Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer CMenaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trialThromb Haemost.(2015 May)
  112. ^Fulton RL, McMurdo ME, Hill A, Abboud RJ, Arnold GP, Struthers AD, Khan F, Vermeer C, Knapen MH, Drummen NE, Witham MDEffect of Vitamin K on Vascular Health and Physical Function in Older People with Vascular Disease--A Randomised Controlled TrialJ Nutr Health Aging.(2016 Mar)
  113. ^Caraballo PJ, Heit JA, Atkinson EJ, Silverstein MD, O'Fallon WM, Castro MR, Melton LJ 3rdLong-term use of oral anticoagulants and the risk of fractureArch Intern Med.(1999 Aug 9-23)
  114. ^Gage BF, Birman-Deych E, Radford MJ, Nilasena DS, Binder EFRisk of osteoporotic fracture in elderly patients taking warfarin: results from the National Registry of Atrial Fibrillation 2Arch Intern Med.(2006 Jan 23)
  115. ^Jamal SA, Browner WS, Bauer DC, Cummings SRWarfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research GroupAnn Intern Med.(1998 May 15)
  116. ^Hodges SJ, Pilkington MJ, Shearer MJ, Bitensky L, Chayen JAge-related changes in the circulating levels of congeners of vitamin K2, menaquinone-7 and menaquinone-8Clin Sci (Lond).(1990 Jan)
  117. ^Pisani P, Renna MD, Conversano F, Casciaro E, Di Paola M, Quarta E, Muratore M, Casciaro SMajor osteoporotic fragility fractures: Risk factor updates and societal impactWorld J Orthop.(2016 Mar 18)
  118. ^Dhanwal DK, Dennison EM, Harvey NC, Cooper CEpidemiology of hip fracture: Worldwide geographic variationIndian J Orthop.(2011 Jan)
  119. ^Johnell O, Kanis JAAn estimate of the worldwide prevalence and disability associated with osteoporotic fracturesOsteoporos Int.(2006 Dec)
  120. ^Fang Y, Hu C, Tao X, Wan Y, Tao FEffect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trialsJ Bone Miner Metab.(2012 Jan)
  121. ^Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJVitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trialsArch Intern Med.(2006 Jun 26)
  122. ^Cheung AM, Tile L, Lee Y, Tomlinson G, Hawker G, Scher J, Hu H, Vieth R, Thompson L, Jamal S, Josse RVitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trialPLoS Med.(2008 Oct 14)
  123. ^Emaus N, Gjesdal CG, Almås B, Christensen M, Grimsgaard AS, Berntsen GK, Salomonsen L, Fønnebø VVitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trialOsteoporos Int.(2010 Oct)
  124. ^Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen EThree-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal womenOsteoporos Int.(2013 Sep)
  125. ^Sasaki N, Kusano E, Takahashi H, Ando Y, Yano K, Tsuda E, Asano YVitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG)J Bone Miner Metab.(2005)
  126. ^Koitaya N, Sekiguchi M, Tousen Y, Nishide Y, Morita A, Yamauchi J, Gando Y, Miyachi M, Aoki M, Komatsu M, Watanabe F, Morishita K, Ishimi YLow-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese womenJ Bone Miner Metab.(2013 May 24)
  127. ^Nowak JK, Grzybowska-Chlebowczyk U, Landowski P, Szaflarska-Poplawska A, Klincewicz B, Adamczak D, Banasiewicz T, Plawski A, Walkowiak JPrevalence and correlates of vitamin K deficiency in children with inflammatory bowel diseaseSci Rep.(2014 Apr 24)
  128. ^Jagannath VA, Fedorowicz Z, Thaker V, Chang ABVitamin K supplementation for cystic fibrosisCochrane Database Syst Rev.(2013 Apr 30)
  129. ^Nakajima S, Iijima H, Egawa S, Shinzaki S, Kondo J, Inoue T, Hayashi Y, Ying J, Mukai A, Akasaka T, Nishida T, Kanto T, Tsujii M, Hayashi NAssociation of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel diseaseNutrition.(2011 Oct)
  130. ^Booth SL, Pennington JA, Sadowski JAFood sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: data from the FDA Total Diet StudyJ Am Diet Assoc.(1996 Feb)
  131. ^Shiratori T, Sato A, Fukuzawa M, Kondo N, Tanno SSevere Dextran-Induced Anaphylactic Shock during Induction of Hypertension-Hypervolemia-Hemodilution Therapy following Subarachnoid HemorrhageCase Rep Crit Care.(2015)
  132. ^Riegert-Johnson DL, Volcheck GWThe incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective reviewAnn Allergy Asthma Immunol.(2002 Oct)
  133. ^Bullen AW, Miller JP, Cunliffe WJ, Losowsky MSSkin reactions caused by vitamin K in patients with liver diseaseBr J Dermatol.(1978 May)
  134. ^Institute of Medicine (US) Panel on MicronutrientsDietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc
  135. ^Fu X, Shen X, Finnan EG, Haytowitz DB, Booth SLMeasurement of Multiple Vitamin K Forms in Processed and Fresh-Cut Pork Products in the U.S. Food SupplyJ Agric Food Chem.(2016 Jun 8)
  136. ^Manoury E, Jourdon K, Boyaval P, Fourcassié PQuantitative measurement of vitamin K2 (menaquinones) in various fermented dairy products using a reliable high-performance liquid chromatography methodJ Dairy Sci.(2013 Mar)
  137. ^Kamao M, Suhara Y, Tsugawa N, Uwano M, Yamaguchi N, Uenishi K, Ishida H, Sasaki S, Okano TVitamin K content of foods and dietary vitamin K intake in Japanese young womenJ Nutr Sci Vitaminol (Tokyo).(2007 Dec)
  138. ^Elder SJ, Haytowitz DB, Howe J, Peterson JW, Booth SLVitamin k contents of meat, dairy, and fast food in the u.s. DietJ Agric Food Chem.(2006 Jan 25)
  139. ^Shimogawara K, Muto SPurification of Chlamydomonas 28-kDa ubiquitinated protein and its identification as ubiquitinated histone H2BArch Biochem Biophys.(1992 Apr)
  140. ^Hirauchi K, Sakano T, Notsumoto S, Nagaoka T, Morimoto A, Fujimoto K, Masuda S, Suzuki YMeasurement of K vitamins in animal tissues by high-performance liquid chromatography with fluorimetric detectionJ Chromatogr.(1989 Dec 29)
  141. ^Chen GC, Wang Y, Tong X, Szeto IMY, Smit G, Li ZN, Qin LQCheese consumption and risk of cardiovascular disease: a meta-analysis of prospective studiesEur J Nutr.(2017 Dec)
  142. ^Villines TC, Hatzigeorgiou C, Feuerstein IM, O'Malley PG, Taylor AJVitamin K1 intake and coronary calcificationCoron Artery Dis.(2005 May)
  143. ^Hao G, Zhang B, Gu M, Chen C, Zhang Q, Zhang G, Cao XVitamin K intake and the risk of fractures: A meta-analysisMedicine (Baltimore).(2017 Apr)
  144. ^Bahadoran Z, Mirmiran P, Kabir A, Azizi F, Ghasemi AThe Nitrate-Independent Blood Pressure-Lowering Effect of Beetroot Juice: A Systematic Review and Meta-AnalysisAdv Nutr.(2017 Nov 15)
  145. ^Lara J, Ashor AW, Oggioni C, Ahluwalia A, Mathers JC, Siervo MEffects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysisEur J Nutr.(2016 Mar)
  146. ^Aune D, Giovannucci E, Boffetta P, Fadnes LT, Keum N, Norat T, Greenwood DC, Riboli E, Vatten LJ, Tonstad SFruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studiesInt J Epidemiol.(2017 Jun 1)
  147. ^Ried KGarlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and ReviewJ Nutr.(2016 Feb)
  148. ^Ried K, Toben C, Fakler PEffect of garlic on serum lipids: an updated meta-analysisNutr Rev.(2013 May)
  149. ^Kodama S, Saito K, Tanaka S, Horikawa C, Fujiwara K, Hirasawa R, Yachi Y, Sone Y, Tada Iida K, Shimano H, Ohashi Y, Yamada N, Sone HFasting and post-challenge glucose as quantitative cardiovascular risk factors: a meta-analysisJ Atheroscler Thromb.(2012)
  150. ^Mannucci E, Dicembrini I, Lauria A, Pozzilli PIs glucose control important for prevention of cardiovascular disease in diabetes?Diabetes Care.(2013 Aug)
  151. ^Lan J, Zhao Y, Dong F, Yan Z, Zheng W, Fan J, Sun GMeta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertensionJ Ethnopharmacol.(2015 Feb 23)
  152. ^Schaffer SW, Jong CJ, Ramila KC, Azuma JPhysiological roles of taurine in heart and muscleJ Biomed Sci.(2010 Aug 24)
  153. ^Ahmadian M, Dabidi Roshan V, Ashourpore ETaurine Supplementation Improves Functional Capacity, Myocardial Oxygen Consumption, and Electrical Activity in Heart FailureJ Diet Suppl.(2017 Jul 4)
  154. ^Ahmadian M, Roshan VD, Aslani E, Stannard SRTaurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failureTher Adv Cardiovasc Dis.(2017 Jul)
  155. ^Beyranvand MR, Khalafi MK, Roshan VD, Choobineh S, Parsa SA, Piranfar MAEffect of taurine supplementation on exercise capacity of patients with heart failureJ Cardiol.(2011 May)
  156. ^Sun Q, Wang B, Li Y, Sun F, Li P, Xia W, Zhou X, Li Q, Wang X, Chen J, Zeng X, Zhao Z, He H, Liu D, Zhu ZTaurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled StudyHypertension.(2016 Mar)
  157. ^Militante JD, Lombardini JBTreatment of hypertension with oral taurine: experimental and clinical studiesAmino Acids.(2002)
  158. ^Kuang H, Yang F, Zhang Y, Wang T, Chen GThe Impact of Egg Nutrient Composition and Its Consumption on Cholesterol Homeostasis.Cholesterol.(2018)
  159. ^Vincent MJ, Allen B, Palacios OM, Haber LT, Maki KCMeta-regression analysis of the effects of dietary cholesterol intake on LDL and HDL cholesterolAm J Clin Nutr.(2019 Jan 1)
  160. ^Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, Hegele RA, Krauss RM, Raal FJ, Schunkert H, Watts GF, Borén J, Fazio S, Horton JD, Masana L, Nicholls SJ, Nordestgaard BG, van de Sluis B, Taskinen MR, Tokgözoglu L, Landmesser U, Laufs U, Wiklund O, Stock JK, Chapman MJ, Catapano ALLow-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus PanelEur Heart J.(2017 Aug 21)
  161. ^Khalighi Sikaroudi M, Soltani S, Kolahdouz-Mohammadi R, Clayton ZS, Fernandez ML, Varse F, Shidfar FThe responses of different dosages of egg consumption on blood lipid profile: An updated systematic review and meta-analysis of randomized clinical trials.J Food Biochem.(2020-08)
  162. ^McNamara DJ, Kolb R, Parker TS, Batwin H, Samuel P, Brown CD, Ahrens EHHeterogeneity of cholesterol homeostasis in man. Response to changes in dietary fat quality and cholesterol quantity.J Clin Invest.(1987-Jun)
  163. ^Herron KL, Vega-Lopez S, Conde K, Ramjiganesh T, Shachter NS, Fernandez MLMen classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolismJ Nutr.(2003 Apr)
  164. ^Sehayek E, Nath C, Heinemann T, McGee M, Seidman CE, Samuel P, Breslow JLU-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary cholesterol absorption in humans.J Lipid Res.(1998-Dec)
  165. ^Nestel PJ, Poyser AChanges in cholesterol synthesis and excretion when cholesterol intake is increased.Metabolism.(1976-Dec)
  166. ^Jacobson TA, Maki KC, Orringer CE, Jones PH, Kris-Etherton P, Sikand G, La Forge R, Daniels SR, Wilson DP, Morris PB, Wild RA, Grundy SM, Daviglus M, Ferdinand KC, Vijayaraghavan K, Deedwania PC, Aberg JA, Liao KP, McKenney JM, Ross JL, Braun LT, Ito MK, Bays HE, Brown WV, Underberg JA,National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2.J Clin Lipidol.(2015)