Anacyclus Pyrethrum (of the family Asteraceae) is a plant and herb from Ayurveda referred to as Akarhara (dried root extract, also called pyrethrin) or Pellitory root while being under the classification of Vajikaran Rasayana with other virility enhancers. It is traditionally used as an aphrodisiac and fertility herb as well as a brain tonic for the treatment of paralysis, hemiplegia, cephalalgia (headache), epilepsy, and rheumatism. It is also thought to 'purge' the body of toxins by stimulating blood flow to the brain and face, and causing increased salivation and mucus flow.
In other places, it is known as akarkarabh or akallaka (North Africa) where it originated only to later be introduced to India. It is also referred to as spanish chamomile due to looking visually similar to the chamomile plant.
Anacyclus pyrethrum is a herb traditionally used for male vitality and virility, with additional benefits in cognition
Anaclcus Pyrethrum tends to contain (root extract unless otherwise specified):
13 Alkylamides mostly based off of isobutylamide of which includes N-isobutyldienediynamide (Pellitorine or Pyrethrine) and Anacylin as the major alkylamides
Polysaccharides in the hot water fragment of solution
The known bioactives of the root extract appear to be the alkylamides, although the composition of this plant are not well known at this moment in time
200-600mg/kg of an ethanolic anacyclus pyrethrum extract 30 minutes prior to an electroshock induced seizure appeared to exert protective effects with the lowest dose being most effective (71.37% recovery) but at a lower potency than 25mg/kg phenytoin. Elsewhere, a hydroalcoholic extract at 50-500mg/kg orally showed protective effects when ingested prior to a pentylenetetrazole-induced seizure (50-100% protection) and a higher dose (100-1,000mg/kg) showed protection against electroshock induced seiure (16.7-50%).
The changes in oxidative biomarkers (enzymes and TBARS) as well as acetylcholinesterase seen with seizures are reduced with pretreatment of anacyclus pyrethrum.
Anacyclus Pyrethrum appears to have anti-convulsive properties which are seen following oral ingestion in rats
2.2. Memory and Cognition
In rats with scopolamine-induced memory impairment, supplementation of an ethanolic extract of anacyclus pyrethrum at 50-200mg/kg was effective in preserving acquisition and retention of memory with the 100-200mg/kg dosage being comparable in potency to the reference drug Piracetam (200mg/kg). Anacyclus pyrethrum also appears to enhance social memory with a potency comparable to piracetam. Anti-amnesiac effects have also been noted in rats with induced seizures (normally reduces cognitive performance) due to the anti-convulsive properties of anacyclus pyrethrum.
This herb appears to have respectable anti-amnesiac properties, although its pro-cognitive properties (for usage as a nootropic) have not yet been evaluated and it does not appear to exceed the reference drug in potency
3Inflammation and Immunology
Anacyclus pyrethrum polysaccharide at 25-50mg/kg (I.P injection) was able to increase the phagocytocic index of macrophages in the range of 50-115% with 10mg/kg and 100mg/kg not being effective, a potency greater than Citrullus colocynthis yet lesser than Alpinia galanga. When tested in vivo, 50-100mg/kg of a petroleum ether extract was able to preserve phagocytosis in the presence of cyclophosphamide.
Anacyclus pyrethrum appears to increase phagocytosis of macrophages and prevent their immunosuppresion
Immune cell count in spleen cells appears to be enhanced with 25-50mg/kg injections of anacyclus pyrethrum polysaccharide, suggesting a mitogenic effect.
Appears to have mitogenic effects, although it is not ascertained which cell populations are stimulated
4Interactions with Hormones
Supplementation of anacyclus pyrethrum ethanolic root extract (50-150mg/kg) over 28 days in rats noted dose-dependent increases in testosterone and luteinizing hormone to approximately two-fold of baseline (exact values not given). It is though anacyclyus works via stimulating the hypothalamus, as the alkylaimde class of molecules (also seen in Spilanthes acmella) have been known to work in this manner.
May increase testosterone in otherwise normal rats alongside its fertility enhancing effects
5Interactions with Sexuality
A water extract of anacyclus pyrethrum at 50-100mg/kg over 28 days appears to possess libido enhancing properties due to enhancing the penile erection index (202%), mounting and intromission frequency (increases of 196-266% and 173-384%, respectively), and latency time for mounting and intromission (82-90% and 63-76% of baseline, respectively). All parameters follow dose and time dependence (100mg/kg outperforming 50mg/kg and 28 days outperforming 15 days) and persisted for up to 15 days after supplementation and similar values have been noted elsewhere with the petroleum ether extract.
Appears to have relatively potent libido enhancing properties which persist for a few weeks after supplement cessation
6Interactions with Organ Systems
Oral ingestion of 50-150mg/kg of an ethanolic root extract of anacyclus pyrethrum over 28 days to male rats appears to causes increases in the weight of the testicles (2.6-12.3%) and in particular both the epididymus (8.6-26.1%) and seminal vesicles (4.3-9.8%). The higher doses were comparable to 0.5mg/kg injections of testosterone and was not associated with any abnormal histological signs and similar changes have been seen with a lyophilized water extract and petroleum ether extract.
In regards to semen the above doses have been noted to increase sperm motility, viability, fructose content, and count.
There appear to be increases in testicular weight and seminal parameters suggest increased fertility in male rats
In rats, oral ingestion of 50-150mg/kg of an ethanolic root extract of anacyclus pyrethrum over 28 days appears to increase the weight of the prostate (7.5-21.5%) associated with androgenic activity. This has been noted elsewhere to a similar but slightly lesser degree.
There appears to be an increase in prostate weight associated with this herb, possibly related to the androgenic activities
300-2,000mg/kg of the ethanolic root extract failed to acutely kill any rats within 24 hours of observation and elsewhere a study noting that '50mg/kg and 100mg/kg were 1/20th and 1/10th of the LD50 suggest that this value has been established at 1,000mg/kg for longterm use (of the petroleum root extract). However, a more prolonged study (90 days) using 1,000mg/kg of the ethanolic extract in rats failed to find any evidence of toxicity.
Toxicological data is preliminary and by no means expansive, but currently it seems like the dosages used for supplements are not associated with any lethality