Chlorogenic Acid

Chlorogenic acid is found in Coffee mostly and a lot of plant compounds; it holds promise in many aspects of health and cognition similar to Bioflavonoids and shares some effects similar to Caffeine but less potent. May decrease the absorption of dietary carbohydrate.

This page features 70 unique references to scientific papers.

Confused about supplements?

Join our FREE 5 day supplement course


All Essential Benefits/Effects/Facts & Information

In Progress

This page on Chlorogenic Acid is currently marked as in-progress. We are still compiling research.

Chlorogenic acid is a phytochemical found in coffee and coffee beans. It has been touted as being able to reduce blood sugar levels and potentially exert an anti-diabetic effect. It has also been implicated in weight loss and exerting an anti-obesity effect, but that is insofar correlation and not necessarily due to chlorogenic acid.

It can be beneficial to supplement, although doses found in food sources are enough for a long-term preventative (anti-diabetic) measure.

Confused about supplements?

Free 5 day supplement course

Things To Know

Also Known As

Coffee bean extract, 5-O-caffeoylquinic acid, 3-O-caffeoylquinic acid Green coffee extract

Do Not Confuse With

Chlorine, Corosolic Acid

Things to Note

  • Chlorogenic acid is found in coffee and espresso, although the amount appears to be unreliable[1]

  • Chlorogenic acid may be one of the compounds in prunes that aids in the laxative effect.[2] It is also in coffee, another well known food laxative

  • Chlorogenic acid has a weak psychostimulatory effect, about a third as potent as Caffeine

  • Chlorogenic acid and Caffeic acid were once thought to be anti-thaminases (compounds that can induce a thiamin (Vitamin B1) deficiency), however, this has since been shown to be false.[3]

Is a Form Of

Goes Well With

  • Some oral hypoglycemics (see full summary)

Does Not Go Well With

  • Dietary carbohydrate (can reduce uptake)

  • Zinc and Iron (can hinder absorption)

Caution Notice

May interact with anti-diabetic medication Medical Disclaimer

How to Take

Recommended dosage, active amounts, other details

Supplemental chlorogenic acid appears to have benefit in the range of 120-300mg oral intake, with higher doses still possibly beneficial (not really tested sufficiently). These doses appear to benefit blood pressure and circulation mostly.

This dose seems to be low enough that moderate to high doses of plants with a rich chlorogenic acid content may confer the benefits listed on this page, this most notably includes Green Coffee Extract.

Confused about supplements?

Free 5 day supplement course

Editors' Thoughts on Chlorogenic Acid

Chlorogenic acid seems to be one of the compounds which exerts it effects in doses found in food sources (primarily coffee); supplementation is not really needed if one consumes coffee, but it would help if one decides to supplement.

Kurtis Frank

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what effects chlorogenic acid has on your body, and how strong these effects are.

Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Blood Pressure Notable - See study
The decrease in systolic blood pressure with chlorogenic acid has reached 15 points systolic in hypertensives (150mmHg systolic initially) and appears to maintain at that level until supplement cessation.
Blood Glucose Minor - See study
Not overly remarkable reductions in blood glucose
Glycemic Control Minor - See study
Slight increase in glycemic control possibly secondary to reducing carbohydrate absorption
Homocysteine Minor - See study
Somewhat high acute spike of homocysteine, which is normally a negative thing. Practical significance of this unknown
Insulin Minor - See study
Spike in insulin was attenuated a bit, secondary to attenuating the rate of glucose absorption. Not overly remarkable
Subjective Well-Being Minor - See study
Chlorogenic acid may have a mood enhancing effect independent of caffeine
Weight Minor Moderate See 2 studies
Although the reductions seen with chlorogenic acid seem remarkable, the studies conducted at this moment in time are somewhat industry influenced

Scientific Research

Table of Contents:

  1. 1 Sources and Structure
    1. 1.1 Sources
    2. 1.2 In Coffee and Green Coffee
    3. 1.3 Structure and Properties
  2. 2 Pharmacology and Metabolism
    1. 2.1 Intestinal Digestion
    2. 2.2 Bioactive metabolites
  3. 3 Interactions with Oxidation
  4. 4 Interactions with Heart Health
    1. 4.1 Homocysteine
    2. 4.2 Blood Pressure
  5. 5 Interactions with Obesity
    1. 5.1 Mechanisms of Action
  6. 6 Neurology
    1. 6.1 Stimulation and Activity
    2. 6.2 Neuroprotection
  7. 7 Epidemiology
  8. 8 Interactions with Carbohydrates
    1. 8.1 Carbohydrate uptake
    2. 8.2 Diabetes risk
    3. 8.3 Mechanisms
  9. 9 Nutrient-Nutrient Interactions
    1. 9.1 Oral Hypoglyemic agents
  10. 10 Safety and Toxicology

1Sources and Structure

1.1. Sources

Chlorogenic acid is a quinic acid conjugate of caffeic acid[4] found in high levels in coffee beans and varying forms of coffee. It is also in:

  • Coffee[5] and Green Coffee;[6] in which 1L of coffee contributes 500-800mg Chlorogenic acid (250-400mg caffeic acid)[7] An average coffee drinker tends to consume 0.5-1g of chlorogenic acids daily.[8]

  • Fruits such as apples, pears, eggplant, tomatoes, and blueberries.[9][10] Strawberries as well.[11]

  • Bamboo[12]

  • Potatoes[9]

  • Hawthorn[13]

  • Athrixia Phylicoides[14]

1.2. In Coffee and Green Coffee

Green Coffee water-soluble extract has been used multiple times in hypertensive persons to reduce blood pressure[15][6] in dosages below 200mg. This is contributed to chlorogenic acid, and specifically its metabolite called ferulic acid, decreasing blood pressure[16] and improving vasoreactivity.[17]

Although benefit can be seen with Chlorogenic acid from coffee, supplementation may be a better option. A compound produced during roasting of coffee beans called HHQ can inhibit the actions of Chlorogenic Acid in vivo;[18] coffee without HHQ shows dose-dependent decreases in blood pressure as a result of Chlorogenic acid, which does not occur with HHQ-containing coffee.[19][20]

Despite sufficient levels of Chlorogenic acid in coffee, supplementing the same dose might confer more benefits due to a higher bioactivity of chlorogenic acid

1.3. Structure and Properties

Structurally, Chlorogenic Acid is a combination of two molecules. It is a caffeic acid molecule bound to a Quinic Acid moiety; the combination is referred to as Chlorogenic Acid, and all three molecules can be bioactive after chlorogenic acid ingestion.[21]

Chlorogenic acid can bind to Bovine Serum Albumin in in vitro assays.[22]

During cooking, chlorogenic acid (via its metabolite caffeic acid) can bind to amino acids to form pigmentation under basic conditions.[23]

2Pharmacology and Metabolism

2.1. Intestinal Digestion

Chlorogenic acid itself does not appear to be taken up in the small intestine, and only up to 8% of it by weight is hydrolyzed into caffeic acid and subsequently absorbed (in rats).[24] Chlorogenic acid is highly not actually detected in plasma after ingestion, only its metabolites,[25] although some human studies do note small percentages of ingested chlorogenic acid in the urine after 2g of consumption (1.7%).[26]

However, if chlorogenic acid reaches the colon there is a chance that the gut microflora can break the quinic bond and release caffeic acid.[27] Chlorogenic acid can also be absorbed at a low amount in the colon,[8] Colonic metabolism and absorption of chlorogenic acid seems to be where most bioactivity occurs.[9]

While in the intestines, chlorogenic acid can bind to and hinder the uptake of dietary Zinc[28] as well as non-heme Iron.[29]

2.2. Bioactive metabolites

When chlorogenic acid is digested, it undergoes metabolism into various bioactive metabolites. One study noted 12 urinary metabolites totaling 55.8% of the oral dose.[26] As mentioned previously, about 1.7% of the ingested chlorogenic acid can leave the urine unchanged, and thus the metabolites are most likely the cause for bioactivity in the body.[26]

Ferulic acid can be produced from chlorogenic acid, and one study noted about 0.8% of a 2g oral dose was detected in the urine as ferulic acid.[26]

Caffeic acid was noted as a urinary metabolite at 1% of the oral dose.[26] Dihydrocaffeic acid appears to be in similar amounts.

About half (49.5%) of ingested chlorogenic acid is metabolised into hippuric acid, and one molecule of chlorogenic acid might be able to produce two molecules of hippuric acid, via metabolism of both the caffeic acid and quinic acid moieties.[26] This appears to be a colonic metabolite, as persons without a colon did not have this molecule in their urine.[26]

Other possible metabolites that have been noted are vanillic acid, benzoic acid, and 3-hydroxyphenylpropinoic acid.[30]

3Interactions with Oxidation

As assessed by Oxygen Radical Absorbance Capacity (ORAC), caffeic acid appears to have similar anti-oxidant potential as chlorogenic acid, and dihydrocaffeic acid has a significantly greater capacity.[31]

4Interactions with Heart Health

4.1. Homocysteine

Coffee consumption per se is associated with higher Homocysteine levels in even healthy persons,[32] and it seems both Caffeine[33] and chlorogenic acid[34] are partly to blame. Homocysteine is seen as a biomarker of cardiovascular disease, and when it increases whatever causes heart diseases tend to also increase.[35]

It is currently not known whether coffee ingestion merely increases the biomarker for cardiovascular disease, or whether it can increase risk.[35][34]

4.2. Blood Pressure

In regards to coffee and blood pressure, it is well established that Caffeine can cause transient (lesser than 3 hour) blood pressure spikes in the hypertensive; however, long-term associations with coffee and blood pressure are unclear according to a recent meta-analysis.[36]

It seems that caffeine is slightly pro-hypertensive compound whereas chlorogenic acid and its metabolites exert a potent anti-hypertensive effect. Green coffee extract (with a high chlorogenic acid content) has been shown to reduce blood pressure in humans[15][6] and this effect is contributed to the metabolite ferulic acid, which increases vasoreactivity[16] and general blood pressure lowering ability.[17]

5Interactions with Obesity

5.1. Mechanisms of Action

Chlorogenic acid may be able to induce body fat loss via acting as a PPARa agonist, and increasing body heat produced.[10] It may also reduce proliferation of new fat cells through its anti-oxidant effects.[37]


6.1. Stimulation and Activity

Chlorogenic acid appears to have a weak psychostimulatory effect in rats, vicariously though caffeic acid and m-coumaric acid.[30] Ferulic acid and 3-hydroxyphenylpropinoic acid had no effects. The degree of increased ambulatory activity was approximately one third that of caffeine at physiologically relevant dosages.[30]

6.2. Neuroprotection

Chlorogenic acid, as well as coffee (both caffeinated and decaf) is able to act as an anti-oxidant in neurons against Hydrogen Peroxide induced stress.[38][39] The effect appears to be mediated through upregulating the anti-oxidant enzyme known as NQO1.[39]

Coffee is known to be associated with protection against Parkinson's Disease over a long period of time as evidence by epidemiology,[40] and this historically has been thought to be due to the Caffeine content. Chlorogenic acid may also preserve dopaminergic neurons by suppressing neuroinflammation.[41]


There has been a noted correlation between Coffee ingestion and less Fat Mass in both rodents and humans, results which are confounded with the inclusion of Caffeine which may suppress fat gain over time. Additionally, there may be social differences between coffee drinkers and non-coffee drinkers leading to weight discrepancies.

There is some evidence, however, that this association between coffee and weight (inverse relation, more coffee being linked to less fat mass) extends to decaffeinated coffee; excluding Caffeine as a variable.[42] Laboratory results, however, suggest that most of the weight loss effects of coffee are done via caffeine (as coffee compared to decaffeinated coffee exerts significant differences in fat mass reduction).[43][44]

There appear to be no differences in lipid metabolism, lipolysis, or direct anti-obesity mechanisms which can be contributed to chlorogenic acid rather than coingestion of caffeine[42] which lays suspicion that the correlation between decaffeinated coffee and weight loss lays not in human biochemistry, but mere caloric displacement (drink calorie free coffee instead of having a treat) or perhaps vicariously through improved glucose tolerance. Either that, or doses in coffee are too low to exert appreciable effects.

8Interactions with Carbohydrates

8.1. Carbohydrate uptake

Chlorogenic acid, at 1g intake, is able to reduce insulin and glucose spikes following a meal without affecting overall levels of insulin or glucose significantly.[45]

Longer term intake can reduce carbohydrate uptake, with the most promising result being 6.9% reduced glucose absorption in the intestines.[46]

8.2. Diabetes risk

Many in vivo studies note that coffee reduces the risk of diabetes and improves glucose tolerance[47][48][49], which is at odds with studies that suggest Caffeine impairs glucose tolerance in healthy individuals. The causation for this difference lies in chlorogenic acid, which appears to exert more of an anti-diabetic effect than caffeine exerts a pro-diabetic effect when dosed in accordance with a cup of coffee.[50]

Although there is some work that suggests no relationship between coffee ingestion and improved glucose tolerance[51][52], the majority of evidence seems to lean towards the 'anti-diabetic' conclusion regardless of caffeinated or decaffeinated.[50][53] The anti-diabetic effects seem to be greatest in the elderly and those who combine caffeine ingestion with weight loss.[42]

8.3. Mechanisms

One of the mechanisms of chlorogenic acid and diabetes prevention could lay in its actions as an alpha-glucosidase inhibitor[54] which reduces the rate or amount of carbohydrate uptake.[55]

Additionally, chlorogenic acid can increase muscular glucose uptake by two means. It can directy stimulate AMPK (non-insulin dependent) as well as phosphorylate Akt (stimulate GLUT4).[56] Direct causation of this may lie with the metabolite of chlorogenic acid, caffeic acid, as chlorogenic acid per se does not increase AMPK phosphorylation in vitro.[57] The specific isoform being activated is AMPKa2.[57]

Chlorogenic acid and related caffeic structures can inhibit the enzyme glucose-6-phosphatase (G6P) in vitro and potentially reduce the amount of glucose produced by the body, which can be seen as therapeutic for glucose control in diabetics.[58] 0.5-1mM of chlorogenic acid, in vitro, has been shown to reduce 40% of active G6P in liver cells[59] and oral administration of 3.5mg/kg bodyweight in rats did not change when the peak of blood sugar after feeding occurred (Tmax), but lowered the severity of the peak (Cmax) and overall exposure to glucose (AUC).[59]

Seems to be a pretty effective carb-blocker; and one that is not well-absorbed where it blocks carbs in the small intestines. Which is good, you don't want to absorb something that should stay in the intestines to do its job.

9Nutrient-Nutrient Interactions

9.1. Oral Hypoglyemic agents

The metabolites of chlorogenic acid, ferulic acid and p-coumaric acid, can potentiate the effects of thiazolidinediones and metformin on increasing glucose uptake into cells.[60] Additionally, the suppression of PPARy by chlorogenic acid and metabolites may be useful in alleviating the known side effects of these medications on fat metabolism and serve as adjunct treatments.[60] These synergisms with ferulic acid extend to muscle cells as well as fat cells.[61]

Vanillic acid, a minor constituent of the metabolites, seems to be able to work against metformin; this is unlikely to occur in vivo from chlorogenic acid supplements due to the high concentration needed.[62]

10Safety and Toxicology

There have been reports of allergies to Green Coffee Beans and thus the extract, although this does not seem to be due to chlorogenic acid.[63] It has been investigated as to whether it is the causative agent in numerous herb-related instances of harm (due to it being in many plants) but does not appear to be causative of harm in and of itself.[64][65]

Doesn't appear to be harmful at all, and a lack of case studies despite chlorogenic acid being very prominent in food sources. That being said, a lack of evidence precedes any conclusions.

Scientific Support & Reference Citations


  1. Microbial metabolism of caffeic acid and its esters chlorogenic and caftaric acids by human faecal microbiota in vitro
  2. Andrade KS, et al Supercritical fluid extraction from spent coffee grounds and coffee husks: antioxidant activity and effect of operational variables on extract composition . Talanta. (2012)
  3. Watanabe T, et al The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension . Clin Exp Hypertens. (2006)
  4. Chlorogenic acids and other cinnamates – nature, occurrence and dietary burden
  5. Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans
  6. Gonthier MP, et al Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats . J Nutr. (2003)
  7. Cho AS, et al Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice . Food Chem Toxicol. (2010)
  8. Mahmood T, et al Effect of maturity on phenolics (phenolic acids and flavonoids) profile of strawberry cultivars and mulberry species from pakistan . Int J Mol Sci. (2012)
  9. Identification and Antioxidant Activity of Novel Chlorogenic Acid Derivatives from Bamboo (Phyllostachys edulis)
  10. Öztürk N, Tunçel M Assessment of phenolic acid content and in vitro antiradical characteristics of hawthorn . J Med Food. (2011)
  11. Chellan N, et al An in vitro assessment of the effect of Athrixia phylicoides DC. aqueous extract on glucose metabolism . Phytomedicine. (2012)
  12. Kozuma K, et al Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects . Hypertens Res. (2005)
  13. Ochiai R, et al Green coffee bean extract improves human vasoreactivity . Hypertens Res. (2004)
  14. Suzuki A, et al Green coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive rats . Hypertens Res. (2002)
  15. Suzuki A, et al Hydroxyhydroquinone interferes with the chlorogenic acid-induced restoration of endothelial function in spontaneously hypertensive rats . Am J Hypertens. (2008)
  16. Yamaguchi T, et al Hydroxyhydroquinone-free coffee: a double-blind, randomized controlled dose-response study of blood pressure . Nutr Metab Cardiovasc Dis. (2008)
  17. Ochiai R, et al Effects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressure . Hypertens Res. (2009)
  18. dos Santos MD, et al Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid . Biol Pharm Bull. (2006)
  19. Jin XL, et al Characterization of hydroxycinnamic acid derivatives binding to bovine serum albumin . Org Biomol Chem. (2012)
  20. Yabuta G, et al Structure of green pigment formed by the reaction of caffeic acid esters (or chlorogenic acid) with a primary amino compound . Biosci Biotechnol Biochem. (2001)
  21. Lafay S, et al Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats . Br J Nutr. (2006)
  22. Azuma K, et al Absorption of chlorogenic acid and caffeic acid in rats after oral administration . J Agric Food Chem. (2000)
  23. Olthof MR, et al Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans . J Nutr. (2003)
  24. Couteau D, et al Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid . J Appl Microbiol. (2001)
  25. Coudray C, et al Short-term ingestion of chlorogenic or caffeic acids decreases zinc but not copper absorption in rats, utilization of stable isotopes and inductively-coupled plasma mass spectrometry technique . Br J Nutr. (1998)
  26. Hurrell RF, Reddy M, Cook JD Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages . Br J Nutr. (1999)
  27. Ohnishi R, et al Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice . Biosci Biotechnol Biochem. (2006)
  28. Ishimoto H, et al Antioxidative properties of functional polyphenols and their metabolites assessed by an ORAC assay . Biosci Biotechnol Biochem. (2012)
  29. Urgert R, et al Heavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteers . Am J Clin Nutr. (2000)
  30. Verhoef P, et al Contribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humans . Am J Clin Nutr. (2002)
  31. Olthof MR, et al Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans . Am J Clin Nutr. (2001)
  32. Mennen LI, et al Homocysteine, cardiovascular disease risk factors, and habitual diet in the French Supplementation with Antioxidant Vitamins and Minerals Study . Am J Clin Nutr. (2002)
  33. Mesas AE, et al The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis . Am J Clin Nutr. (2011)
  34. Hsu CL, Huang SL, Yen GC Inhibitory effect of phenolic acids on the proliferation of 3T3-L1 preadipocytes in relation to their antioxidant activity . J Agric Food Chem. (2006)
  35. Cho ES, et al Attenuation of oxidative neuronal cell death by coffee phenolic phytochemicals . Mutat Res. (2009)
  36. Kim J, et al Caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid up-regulate NQO1 expression and prevent H₂O₂-induced apoptosis in primary cortical neurons . Neurochem Int. (2012)
  37. Higdon JV, Frei B Coffee and health: a review of recent human research . Crit Rev Food Sci Nutr. (2006)
  38. Shen W, et al Chlorogenic acid inhibits LPS-induced microglial activation and improves survival of dopaminergic neurons . Brain Res Bull. (2012)
  39. Greenberg JA, et al Coffee, tea and diabetes: the role of weight loss and caffeine . Int J Obes (Lond). (2005)
  40. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals
  41. Bracco D, et al Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women . Am J Physiol. (1995)
  42. van Dijk AE, et al Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance . Diabetes Care. (2009)
  43. Thom E The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people . J Int Med Res. (2007)
  44. Rosengren A, et al Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study . J Intern Med. (2004)
  45. Coffee Consumption and Risk for Type 2 Diabetes Mellitus
  46. van Dam RM, Feskens EJ Coffee consumption and risk of type 2 diabetes mellitus . Lancet. (2002)
  47. Greenberg JA, Boozer CN, Geliebter A Coffee, diabetes, and weight control . Am J Clin Nutr. (2006)
  48. Mackenzie T, Brooks B, O'Connor G Beverage intake, diabetes, and glucose control of adults in America . Ann Epidemiol. (2006)
  49. Coffee Consumption and the Incidence of Type 2 Diabetes
  50. Huxley R, et al Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis . Arch Intern Med. (2009)
  51. Benalla W, Bellahcen S, Bnouham M Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors . Curr Diabetes Rev. (2010)
  52. Tunnicliffe JM, et al Chlorogenic acid differentially affects postprandial glucose and glucose-dependent insulinotropic polypeptide response in rats . Appl Physiol Nutr Metab. (2011)
  53. Ong KW, Hsu A, Tan BK Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes . PLoS One. (2012)
  54. Tsuda S, et al Coffee polyphenol caffeic acid but not chlorogenic acid increases 5'AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscle . J Nutr Biochem. (2012)
  55. Henry-Vitrac C, et al Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract . J Agric Food Chem. (2010)
  56. Bassoli BK, et al Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia . Cell Biochem Funct. (2008)
  57. Prabhakar PK, Doble M Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes . J Agric Food Chem. (2011)
  58. Prabhakar PK, Doble M Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes . Phytomedicine. (2009)
  59. Prabhakar PK, Doble M Interaction of phytochemicals with hypoglycemic drugs on glucose uptake in L6 myotubes . Phytomedicine. (2011)
  60. Layton LL, et al Atopic hypersensitivity to a protein of the green coffee bean and absence of allergic reactions to chlorogenic acid, low-molecular-weight components of green coffee, or to roasted coffee . Int Arch Allergy Appl Immunol. (1965)
  61. Li BQ, et al Role of chlorogenic acid in the toxicity induced by Chinese herbal injections . Drug Chem Toxicol. (2010)
  62. Wu X, et al Comprehensive research and evaluation of chlorogenic acid allergy . Zhongguo Zhong Yao Za Zhi. (2010)
  63. Crozier TW, et al Espresso coffees, caffeine and chlorogenic acid intake: potential health implications . Food Funct. (2012)
  64. Stacewicz-Sapuntzakis M, et al Chemical composition and potential health effects of prunes: a functional food . Crit Rev Food Sci Nutr. (2001)
  65. Horman I, Brambilla E, Stalder R Evidence against the reported antithiamine effect of caffeic and chlorogenic acids . Int J Vitam Nutr Res. (1981)
  66. Cropley V, et al Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study . Psychopharmacology (Berl). (2012)
  67. Thom E The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people . J Int Med Res. (2007)
  68. Watanabe T, et al The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension . Clin Exp Hypertens. (2006)
  69. Olthof MR, et al Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans . Am J Clin Nutr. (2001)
  70. van Dijk AE, et al Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance . Diabetes Care. (2009)