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Cognitive Decline Overview:
Supplements catered to or otherwise known to reduce the rate of cognitive aging. Supplements in this list are chosen for human evidence if present, but reliability or potency are also considered.These supplements may have memory enhancing and cognitive enhancing properties that are unique to a state of cognitive decline (reversing a decline does not inherently have an effect if no decline is present).
120g of blueberry refers to the weight of fresh fruits, and is the higher level of intake for blueberry supplementation if using food products (60-120g being the ideal range). The blueberry page has information on product dosing, but an anthocyanin dose (the active ingredients) in the 500-1,000mg range is desired; fruits confer the same benefits as supplementation.
Blueberries have a large amount of animal evidence to support a reduction of cognitive decline when taken daily, and preliminary human evidence supports improvements in cognition with dietary blueberry intake.
(While the following supplement cannot yet be recommended in this stack, if you are interested in food products against cognitive decline look into dimocarpus longan).
Although there is currently no human evidence to support the usage of spirulina for helping cognitive decline, the animal evidence suggests a remarkable degree of potency in attenuating cognitive decline associated with excess oxidation and inflammation.
10g of spirulina seems to be the highest recommended dose (it is not clear if higher doses are better or not). Otherwise, a supplemental dose of 1-3g is still somewhat effective.
Piracetam is the typical racetam drug, and appears to have a fairly large body of evidence to support its benefits to persons experiencing organic cognitive decline (organic meaning it happened naturally, and wasn't the result of a stroke or head injury).
While piracetam is effective, various other racetam compounds may also be effective if not more-so but currently do not have enough evidence to recommend in this stack. These include noopept and oxiracetam mostly as they seem to have effects very similar to piracetam in the body, whereas other racetams may also benefit cognitive decline but have slightly differing mechanisms.
240-360mg of a particular extract known as EGb-761 (or anything that has approximately 24% 'ginkgoflavones' and 6% 'terpenoids') over the course of the day, usually in three divided doses with meals (80-120mg each time) appears to be effective in reducing the cognitive impairment associated with cognitive decline.
The actual development of dementia or Alzheimer's over time (risk of cognitive decline) does not appear to be influenced though, and ginkgo seems to be therapeutic but not preventative.