IMPORTANT NOTICE: The stack pages are not being updated and have been kept for archival purposes.
Due to the extreme complexity of stacking with proper consideration to demographics such as age, requirements, and gender, we have released a far more encompassing fit - The Supplement Guides
With FREE lifetime updates and authored by over a dozen researchers, it is the clearest guide to supplementation there is.
Aging can be seen as either chronological (pushing your numerical age as high as you can) or an aging phenotype (what it looks like, to yourself and others, as you age). Compounds that promote lifespan as well as compounds that promote a youthful phenotype are both commonly called 'anti-aging' supplements.Chronological anti-aging supplements are 'adding years to life', whereas Youthful phenotype supplements are those that 'add life to your years'.Compounds that fall into the former category (chronological) are quite minimal, and due to the nature of studying these compounds over a long period of time they are not too well backed by current science either.Relative to that, the supplements that promote a youthful phenotype are plenty.> This list compiles the most promising, the most commonly used, and if possible some proven supplements for anti-aging. This list is not a list of 'proven supplements to stop aging' because that proof does not exist at this moment in time
A hormone that is precursor to androgens and estrogens, has been associated with promoting a youthful phenotype and improving physical and cognitive function in the elderly. Is not the most reliable supplement, and has not been shown to extend the amount of years lived.
Preserves a youthful phenotype in regards to circulatory health, and at low doses can promote blood flow and possibly benefit insulin resistance. Higher doses may improve cerebral blood flow and possibly cognition, although the latter claim is not fully studied.
Resveratrol does not appear to actually extend life, although it may extend the median survival time of research animals by reducing the onset of cardiac death.
This herb itself and its active saponin (Astragaloside IV, also known as TA-65 and taken at a much lower dosage) seem to be able to promote a youthful phenotype in older animals, but has not yet been shown to extend lifespan.
3g of the polysaccharides of Ganoderma Lucidum (Reishi or Ling Zhi as alternate names) has been touted to improve vitality and normalize immunological abnormalities (easier sickness, usually) associated with aging. Many of these claims are from Chinese Medicine (where the mushroom is dubbed '10,000 years mushroom') and from Kampo (Japanese) medicine, where Reishi is referred to as the 'Mushroom of Immortality'.
Has not been demonstrated to increase lifespan, but may aid the aging phenotype.
100mg taken thrice a day (totalling 300mg) is implicated in reducing stress and improving cognition in the elderly.
Touted to increase longevity and improve a youthful phenotype through proliferating mitochondria, the cellular energy house. It has repeatedly been shown to proliferate mitochondria in mice, and is a pseudo-vitamin (lacks the essential vitamin tag due to no true deficiency state). Implicated in increasing cognition and well being in the elderly
Severely understudied in humans with no direct research on life extension.
Carnitine, especially Acetyl-L-Carnitine, appears to be elevated to vitamin-like status when in deficiency states. One of the deficiency states appears to be aging, where the normally defunct claims of 'burning fat and building muscle' may actually be relevant, unlike youth where it is ineffective.
L-Carnitine, GPLC, and LCLT are all acceptable; commonly used with Alpha-Lipoic Acid.
250mg is the maintenance dose, with acute usage of up to 1-1.5g daily (in 4-6 divided doses) used therapeutically for 1-2 weeks.
Sold as the pharmaceutical 'Lucidril' and is implicated in aiding cognition/memory in the elderly, especially those with some genetic susceptibility or family relations to Alzheimer's Disease.
Commonly used with L-Carnitine, ALA is a fatty acid which serves as a REDOX anti/pro oxidant and may help regulate oxidative stress. Also linked to acting similar to leptin, suppressing appetite and stimulating glucose uptake into fat and muscle tissue.
Touted to increase lifespan, with mixed results in mice (too unreliable to make conclusions); seems to be capable of adding life to years, however, especially secondary to weight loss that may come from ALA (appetite suppression, at least in animals).
2000 IU Vitamin D appears to be the lower end of what is recommended or otherwise seen to improve median lifespan (in epidemiological research) secondary to reduced mortality. This is most likely related to reducing falls in the eldery, but is still a form of 'life extension' and one of the only ones in this list shown to be related to improved functionality in the elderly.
Consider reducing the dose to 1,000IU vitamin D if you are a Caucasian or person with otherwise light skin in an environment with a large amount of sun exposure (close to the equator during summer)