Studies related to DNA Damage and Vitamin E

Pro-oxidant Effect Of Alpha-tocopherol In Patients With Type 2 Diabetes After An Oral Glucose Tolerance Test--a Randomised Controlled Trial

Effect None
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 19
Gender Both Genders
Age Range 45-64
Body Types Obese, Overweight
Notes for this study:
In type 2 diabetics given high dose alpha-tocopherol supplements (1,200 IU) daily for four weeks, while baseline DNA damage did not appear to be altered the increase in oxidation expected after an oral glucose tolerance test was exacerbated resulting in 13.6% more DNA damage relative to placebo.

Pro-oxidant Effect Of Alpha-tocopherol In Patients With Type 2 Diabetes After An Oral Glucose Tolerance Test--a Randomised Controlled Trial

Effect Increase
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 19
Gender Both Genders
Age Range 45-64
Body Types Obese, Overweight
Notes for this study:
In type 2 diabetics given high dose alpha-tocopherol supplements (1,200 IU) daily for four weeks, while baseline DNA damage did not appear to be altered the increase in oxidation expected after an oral glucose tolerance test was exacerbated resulting in 13.6% more DNA damage relative to placebo.

Increased DNA Oxidative Susceptibility Without Increased Plasma LDL Oxidizability In Type II Diabetes: Effects Of Alpha-tocopherol Supplementation

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 40
Gender Both Genders
Age Range 45-64
Body Types Obese
Notes for this study:
Supplementation of 400IU alpha-tocopherol daily for eight weeks in type II diabetics noted that, despite diabetics having higher baseline DNA oxidative damage relative to nondiabetics, that supplemental vitamin E failed to modify this as well as LDL oxidation.