Studies related to Dysmenorrhea and Vitamin E

A Randomised Controlled Trial Of Vitamin E In The Treatment Of Primary Dysmenorrhoea

Effect Decrease
Trial Design Double blind
Trial Length 1-2 Weeks
Number of Subjects 278
Gender Female
Age Range 13-17
Notes for this study:
Girls aged 15-17 in secondary school in Tehran, Iran with primary dysmenorrhea were treated with 200IU vitamin E twice daily from two days before to three days after the onset of menstruation for four months. Compared to the placebo group, pain score via a visual analogue scale was decreased at 2 months (3 vs. 5) and 4 months (0.5 vs. 6). Duration of pain (in hours) was also reduced at two months (4.2 vs. 15.4) and four months (1.6 vs. 16.7) as was ibuprofen use in subjects (4.3% vs. 89.4% of subjects used it). Pictorial Blood Loss Assessment Chart (PBLAC) scores (to measure amount of menstrual flow) were also reduced at 2 months (54 vs. 70) and 4 months (46 vs. 70). All scores listed are vitamin E vs. placebo, and all differences were statistically significant at p < 0.001.

Evaluation Of The Effect Of Vitamin E On Pelvic Pain Reduction In Women Suffering From Primary Dysmenorrhea

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 120
Gender Female
Age Range 18-29
Notes for this study:
Women aged 18-25 with primary dysmenorrhea were treated with either 400IU/day vitamin E or placebo for 2 days before through 3 days after the onset of menstruation for two cycles for a total of 2 months. The mean reduction of pain on a visual analogue scale was -2.7 in the vitamin E group and -1.8 in the control group at the second month of the study (p=0.04).

A Randomised Placebo-controlled Trial To Determine The Effect Of Vitamin E In Treatment Of Primary Dysmenorrhoea

Effect Decrease
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 100
Gender Female
Age Range 13-17, 18-29
Notes for this study:
5 tablets a day of 100IU vitamin E reduced pain associated with primary dysmenorrhea as measured by a visual analogue scale when taken two days before through 3 days after in onset of menstruation.