Studies related to Endothelin-1 and Vitamin E

The Effect Of Vitamin E On Endothelial Function Of Micro- And Macrocirculation And Left Ventricular Function In Type 1 And Type 2 Diabetic Patients

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 63
Sex Both Genders
Age Range 18-29, 30-44, 45-64
Body Types Obese, Overweight
Notes for this study:
A high dose of vitamin E (1,800 IU) daily for one year in diabetic persons appeared to slightly worsen systolic blood pressure and blood flow (flow mediated dilation and nitroglycerin-induced dilation) whereas positive changes in HbA1c and total cholesterol appeared to be attenuated with vitamin E (relative to placebo) although HbA1c was not significant.

Endothelin was increased with vitamin E at six months, but this change was no longer significant at 12 months; degree of change was minor.