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Studies related to Prostaglandin E2 and Vitamin E

Vitamin E Supplementation Enhances Cell-mediated Immunity In Healthy Elderly Subjects

Effect Decrease
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 32
Sex Both Genders
Age Range 65+
Notes for this study:
30 days supplementation of vitamin E as alpha-tocopherol (800mg) to otherwise healthy older adults appeared to increase immunity (DTH reactivity) and IL-2 concentrations and the mitogenic response to a mitogen (concavalin A) by 67+/-24% and 24% respectively.

These changes were associated with a reduction in PGE2 secretion from immune cells and a decrease in lipid peroxidation in plasma.