Studies related to Immunoglobulin G and Vitamin E

Vitamin E Supplementation Enhances Cell-mediated Immunity In Healthy Elderly Subjects

Effect None
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 32
Gender Both Genders
Age Range 65+
Notes for this study:
30 days supplementation of vitamin E as alpha-tocopherol (800mg) to otherwise healthy older adults appeared to increase immunity (DTH reactivity) and IL-2 concentrations and the mitogenic response to a mitogen (concavalin A) by 67+/-24% and 24% respectively.

These changes were associated with a reduction in PGE2 secretion from immune cells and a decrease in lipid peroxidation in plasma.

Effects Of Supplementation With Tocotrienol-rich Fraction On Immune Response To Tetanus Toxoid Immunization In Normal Healthy Volunteers

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 108
Gender Female
Age Range 18-29
Notes for this study:
Supplementation of a mixed vitamin E supplement at 400mg (70% tocotrienols and 30% tocopherols conferring 180 IU of alpha-tocopherol) for two months in which a vaccination was given after one month supplementation was associated with a significantly enhanced production of cytokines (IL-4, IgG, and IFNy) and a better response to the tetanus vaccination compared to placebo.