Vitamin E Supplementation Enhances Cell-mediated Immunity In Healthy Elderly Subjects
| Effect | None |
| Trial Design | Double blind |
| Trial Length | 2-4 Weeks |
| Number of Subjects | 32 |
| Gender | Both Genders |
| Age Range | 65+ |
30 days supplementation of vitamin E as alpha-tocopherol (800mg) to otherwise healthy older adults appeared to increase immunity (DTH reactivity) and IL-2 concentrations and the mitogenic response to a mitogen (concavalin A) by 67+/-24% and 24% respectively.
These changes were associated with a reduction in PGE2 secretion from immune cells and a decrease in lipid peroxidation in plasma.
| Effect | Increase |
| Trial Design | Double blind |
| Trial Length | 1-6 months |
| Number of Subjects | 108 |
| Gender | Female |
| Age Range | 18-29 |
Supplementation of a mixed vitamin E supplement at 400mg (70% tocotrienols and 30% tocopherols conferring 180 IU of alpha-tocopherol) for two months in which a vaccination was given after one month supplementation was associated with a significantly enhanced production of cytokines (IL-4, IgG, and IFNy) and a better response to the tetanus vaccination compared to placebo.