Effects Of Long-term Vitamin E Supplementation On Cardiovascular Events And Cancer: A Randomized Controlled Trial

Effect Decrease
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 3994
Gender Both Genders
Age Range 45-64, 65+
Body Types Overweight
Notes for this study:
In a three year extension of the HOPE trial which gave persons over the age of 55 (preexisting diabetes or cardiovascular ailments) supplementation of 400 IU vitamin E, there appeared to be an increase in heart failure rates relative to placebo associated with a greater rate of decline in LVEF. Despite the increase in heart failure, overall cardiovascular mortality was not changed.

No benefit nor harm was noted for cancers in this study.

The Effect Of Vitamin E On Endothelial Function Of Micro- And Macrocirculation And Left Ventricular Function In Type 1 And Type 2 Diabetic Patients

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 63
Gender Both Genders
Age Range 18-29, 30-44, 45-64
Body Types Obese, Overweight
Notes for this study:
A high dose of vitamin E (1,800 IU) daily for one year in diabetic persons appeared to slightly worsen systolic blood pressure and blood flow (flow mediated dilation and nitroglycerin-induced dilation) whereas positive changes in HbA1c and total cholesterol appeared to be attenuated with vitamin E (relative to placebo) although HbA1c was not significant.

Endothelin was increased with vitamin E at six months, but this change was no longer significant at 12 months; degree of change was minor.