Studies related to Diarrhea and Lactase enzyme

The Effect Of Oral Supplementation With Lactobacillus Reuteri Or Tilactase In Lactose Intolerant Patients: Randomized Trial

Effect Decrease
Values 0-10 scale, 10 is most severe. Mean and SD. Placebo: before 6.10 ± 0.79, after 5.90 ± 0.85. Lactase: before 5.95 ± 1.60, after 0.20 ± 0.41.
Trial Design Randomized trial
Trial Length 24 hours
Number of Subjects 40
Sex Both Genders
Age Range 18-29, 30-44, 45-64, 65+
Notes for this study:
In a randomized trial with unclear blinding, 60 participants with lactase intolerance were given placebo, 9000 units of tilactase, or lactobacillus reuteri with 25 g of lactose. For our purposes, placebo vs. tilactase is the relevant comparison.

The lactase group saw a considerable reduction in breath hydrogen, which was statistically significant compared with the placebo. They also saw substantially larger reductions in bloating, abdominal pain, flatulence, diarrhea.
Funding issues for this study:
Unclear funding.

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