Effects Of Exogenous Lactase Administration On Hydrogen Breath Excretion And Intestinal Symptoms In Patients Presenting Lactose Malabsorption And Intolerance
Notes for this study:
||21.88% became negative with a reduction of 74.95 PPM to 7.85. 17.71% saw a reduction with levels changing from 187.7 to 66.64, and 60.41% saw no effect, with levels increasing from 81.6 to 94.43
|Number of Subjects
In an uncontrolled trial, 96 people with lactose intolerance underwent a 25 g lactose challenge and breath hydrogen test at baseline and then with 15000 Units of an acid-resistant beta-galactosidase (tilactase) simultaneously with 25 grams of lactose a minimum of 8 days later.
The supplement caused 21.88% of the participants to became negative (group A) for breath hydrogen, 17.71% saw a notable reduction (group B), and 60.41% didn't see an effect (group C).
Interestingly, group C saw a notable, statistically significant reduction in abdominal pain, while group A saw a smaller, nonsignificant reduction, and group B didn't see a reduction. Groups A and C saw statistically significant reductions in bloating, but not group B. Group B saw a statistically significant decrease in nausea, while the other groups saw nonsignificant reductions (nausea wasn't very severe), and groups B and C saw significant reductions in diarrhea, while the reduction in group A was nonsignificant, though the baseline was lower than for B and C.